Many of the body's processes follow a natural daily rhythm or so-called circadian clock, so there are certain times of the day when a person is most alert, when the heart is most efficient, and when the body prefers sleep. Even bacteria have a circadian clock, and in a December 10 Cell Reports study, researchers designed synthetic microbes to learn what drives this clock and how it might be manipulated.
"The answer seems to be especially simple: the clock proteins sense the metabolic activity in the cell," says senior author Michael Rust, of the University of Chicago's Institute for Genomics and Systems Biology.