Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. His work is being published today in a cover article in a top scientific journal - Molecular Cell.

Gewirth’s study confirms his 2001 hypothesis that this protein – GRP94 – is from the same family as the better known HSP90 proteins. As ligand-regulated chaperones – proteins that help other cellular proteins achieve their active shapes, the HSP90s are key players in cellular regulation and recognition.

Were Neanderthals direct ancestors of contemporary humans or an evolutionary side branch that eventually died out?

This is one of the enduring questions in human evolution as scientists explore the relationship of fossil groups, such as Neanderthals, with people alive today.

The simultaneous publication of two studies with Neanderthal nuclear DNA sequences [1,2] was a technological breakthrough that held promise for answering a longstanding question in human evolution: Did “archaic” groups of humans, such as Neanderthals, make any substantial contribution to the extant human gene pool? The conclusions of the two studies, however, were puzzling and possibly contradictory.

The cow as killer of the climate: this more recent portrayal of our bovine friends is because their digestion causes them to produce methane almost continuously and pound for pound methane has a much larger impact on global warming than carbon dioxide.

Now a team of German and Czech scientists say these animals also boost the production of methane from soil.

Grass lands that are not used for crops generally act as sinks for greenhouse gases like methane, carbon dioxide and nitrous oxide. However, once these grasslands become pastures for cattle a change occurs. This was especially noticeable in the winter, when cows stayed in a smaller area, reducing the spread of waste and increasing the density of the soil due to the animals' weight.

Researchers in the UK are gearing themselves up for an influx of help. Forty thousand people have already run the LHC@home program on their home or office computers, to help scientists discover the secrets of matter and this week researchers at Queen Mary, University of London, officially launched the new base for LHC@home, which has moved from CERN, the European particle physics laboratory in Geneva.

LHC@home is a collaboration between CERN, the Helsinki Institute of Physics, the Niels Bohr Institute in Copenhagen, Queen Mary University of London and TRIUMF in Vancouver.

The Norwegian Nobel Committee has decided that the Nobel Peace Prize for 2007 is to be shared, in two equal parts, between the Intergovernmental Panel on Climate Change (IPCC) and Albert Arnold (Al) Gore Jr. for their efforts to build up and disseminate greater knowledge about man-made climate change, and to lay the foundations for the measures that are needed to counteract such change.

How do global warming studies merit a peace prize?

In the words of the committee, extensive climate changes may alter and threaten the living conditions of much of mankind, inducing large-scale migration and greater competition for the earth's resources.

The enzyme TPPII may contribute to obesity by stimulating the formation of fat cells, suggests a study in EMBO reports this week. The enzyme, TPPII, has previously been linked to making people feel hungry, but Jonathan Graff and colleagues now show that it may be even more deeply involved in causing obesity.

The team found that TPPII actually stimulated the formation of fat cells in worms and mammalian cells and that by reducing it, fat stores decreased. Mice with lower levels of TPPII were thinner than their wild type littermates, although their food intake was comparable.

Statins are known to be good for lowering cholesterol and maybe even fighting dementia, and now they have another reported benefit: they appear to slow decline in lung function in the elderly— even in those who smoke. According to researchers in Boston, it may be statins’ anti-inflammatory and antioxidant properties that help achieve this effect.

Their findings were published in the second issue for October in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

“We hypothesized that statins would have a protective effect on decline in lung function,” wrote Dr.

Central venous catheters are commonly used to provide permanent hemodialysis for patients with serious kidney disease. One technique, inserting a catheter through large vessels, has been commonly used worldwide in recent years.

A new study published in Hemodialysis International finds that this treatment may block the blood flow in the vessel, leading to superior vena cava syndrome (SVC syndrome), a highly serious complication caused by the obstruction of blood coming to the heart from the upper body.

The warning signs of SVC syndrome include shortness of breath, swelling of the upper limbs, neck and face, which occur as the catheter, generally inserted into a large blood vessel, blocks blood flow.

For the first time, scientists have linked the all-too-human preference for a food — chocolate — to a specific, chemical signature that may be programmed into the metabolic system and is detectable by laboratory tests. The signature reads ‘chocolate lover’ in some people and indifference to the popular sweet in others, the researchers say.

The study by Swiss and British scientists breaks new ground in a rapidly emerging field that may eventually classify individuals on the basis of their metabolic type, or metabotype, which can ultimately be used to design healthier diets that are customized to an individual’s needs. The study is scheduled for publication in the Nov.

Biophysicists at the University of Pennsylvania have discovered that the nuclei of human stem cells are particularly soft and flexible, rather than hard, making it easier for stem cells to migrate through the body and to adopt different shapes, but ultimately to put human genes in the correct nuclear ¡°sector¡± for proper access and expression.

Researchers pulled cell nuclei into microscopic glass tubes under controlled pressures and visualized the shear of the DNA and associated proteins by fluorescence microscopy. The study showed that nuclei in human embryonic stem cells were the most deformable, followed by hematopoietic stem cells, HSCs, that generate a wide range of blood and tissue cells.