MIT researchers have shown that cells from different people don't all react the same way when exposed to the same DNA-damaging agent, a finding that could help clinicians predict how patients will respond to chemotherapy.
The research team from MIT's Center for Environmental Health Sciences (CEHS) and the Departments of Biological Engineering and Biology, identified a group of 48 genes that can predict how susceptible an individual is to the toxic compound, known as MNNG. The work appears in Genes and Development.
MNNG, a DNA-damaging compound similar to toxic chemicals found in tobacco smoke and in common chemotherapy agents, usually kills cells by inducing irreparable DNA damage. However, the researchers found a wide range of susceptibility among cells taken from healthy people.