The current Ebola virus outbreak in West Africa has claimed more than 2000 lives and has spurred calls for a deeper understanding of the molecular biology of the virus that could be critical in the development of vaccines or antiviral drugs to treat or prevent Ebola hemorrhagic fever.
A team at the University of Virginia, under the leadership of Dr. Dan Engel, a virologist, and Dr. Zygmunt Derewenda, a structural biologist, has obtained the crystal structure of a key protein involved in Ebola virus replication, the C-terminal domain of the Zaire Ebola virus nucleoprotein (NP).