People with a rare autoimmune disorder produce autoimmune antibodies that appear to be linked to a reduced occurrence of Type 1 diabetes, new research has found. The study, published in Cell, suggests these antibodies could limit immune-related diseases and may have therapeutic potential.
In an international study led by King's College London, samples were taken from 81 people with a rare autoimmune disorder, called autoimmune polyendocrine syndrome type 1 (APECED), who have defects in the autoimmune regulator gene. Defects in this gene mean it can no longer fulfil its role as a regulator that helps purge the body of autoreactive immune cells termed T cells that can react against the body's own proteins, mistaking them for a foreign invader.