Isotretinoin (popularly marketed as Accutane) is used to treat severe acne and has been approved in Canada since 1983. The average age of isotretinoin users in Canada is estimated to be 24 years, and half of all prescriptions are written for females, a concern because it can severely harm a fetus, causing craniofacial, cardiac and central nervous system defects, as well as a high likelihood of miscarriage or medical termination.
Even Canada's program recommends informed written consent, two negative pregnancy tests before beginning treatment and the use of two reliable birth control methods during treatment, numerous studies in Canada and internationally have indicated poor adherence to pregnancy prevention guidelines among women taking isotretinoin.