A widely used class of diabetes medications appears to be associated with an increased risk for fractures, according to a report in the April 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

“The insulin-sensitizing thiazolidinediones are a relatively new and effective class of oral antidiabetic agents that have gained wide use in clinical conditions characterized by insulin resistance,” the authors write as background information in the article. Two drugs in this category, pioglitazone and rosiglitazone, account for 21 percent of oral diabetes medications prescribed in the United States and 5 percent of those in Europe. Recent studies have suggested that these therapies may have unfavorable effects on bone, resulting in slower bone formation and faster bone loss.

Young women who took the commonly used epilepsy drug phenytoin for one year showed significant bone loss compared to women taking other epilepsy drugs, according to a study published in the April 29, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology.

Researchers tested the bone health of 93 women with epilepsy who were between the ages of 18 and 40 and were taking the epilepsy drugs phenytoin, carbamazepine, lamotrigine or valproate. Bone mineral density was measured at the spine and two areas of the hip, (the femoral neck and total hip) at the beginning of the study and one year later. Researchers also evaluated each woman’s nutrition and physical activity, along with other factors that affect bone health.

CHICAGO, April 28 /PRNewswire/ --

- Three-day Forum Will Highlight Economic Development, Education, Environment Issues

Chicago Mayor Richard M. Daley today welcomes municipal leaders from throughout the United States, Canada and Arab world for the first-ever U.S.-Arab Cities Forum, aimed at sharing information and implementing strategies to build local economies that are competitive in the global society.

The Forum, whose working sessions will be held at the University of Illinois-Chicago's Conference Center April 28-30, is co-hosted by Mayor Daley and Chicago's Sister City partners, Mayor Omar Maani of Amman, Jordan, and Mayor Mohamed Sajid of Casablanca, Morocco.

Are climate change and carbon emissions inextricably linked? New research published in Carbon Balance and Management suggests that this may not be the case, although it may be some time before we reach this saturation point.

The land and the oceans contain significantly more carbon than the atmosphere, and exchange carbon dioxide with the atmosphere. The amount of CO2 emissions absorbed by the land or the oceans vary in response to changes in climate (including natural variations such as El Nino or volcanic eruptions). So current theories suggest that climate change will have a feedback effect on the rate that atmospheric CO2 increases; rising CO2 levels in turn add to global warming.

The link between the carbon cycle, and human effects caused by emissions, energy use and agriculture, may only be relevant for the next 'several centuries,’ suggest Igor Mokhov and Alexey Eliseev from the A.M. Obukhov Institute of Atmospheric Physics RAS, in Moscow, Russia. The authors used a climate model known as IAP RAS CM to study how feedback between our climate and the carbon cycle changes over time. In their simulations, the authors assumed that fossil fuel emissions would grow exponentially with a characteristic timescale from 50 to 250years.

Nitric oxide has emerged as an important signaling molecule in plants - as in mammals including people. In studies of a tropical medicinal herb as a model plant, researchers have found that nitric oxide targets a number of proteins and enzymes in plants.

In collaborative work with the research group of Renu Deswal, a faculty member, and her doctoral student at the Botany Department, University of Delhi, India, Agricultural Research Service (ARS) scientist Autar Mattoo has identified 19 such targeted proteins and enzymes in Kalanchoe pinnata, also known as "miracle leaf."

These proteins and enzymes are involved in regulating processes from seed germination to cell development to plant death.

TAIPEI, Taiwan, April 28 /PRNewswire/ --

- In Five of 22 Categories at Least One Taiwan Institution Ranks Within the World's Top 100 for 2003-2007 Period

As a futurist I speak and write about trends and the future. I am often asked questions about the future of one thing or another. In most cases I speak to general trends, not specific outcomes. In some areas I can be somewhat specific as I have taken the time to analyze and then cross reference what I have learned with the trends and forces I see. One of those areas is the price of oil. In early 2007, when the price of oil was $53 a barrel I was invited on a business program to predict what I thought the price of oil might be by the end of the year. At that time I said that I thought that oil would exceed $80 a barrel and could well approach $100, though I didn’t think it would cross that barrier in 2007. The reporter, who had never spoken with a futurist, calling me a ‘so-called futurist’ was trying to contain her sputtering disbelief. The opposite side was some ‘oil industry analyst’ who spoke about a price fluctuation between $50-70 for the remainder of the year. About eight months ago, I wrote that I thought that the near term trading range for the price of oil for the next couple of years would be $80-125. At the time I stated that while there was little on the horizon to create a downward pressure below $80, there was much on the horizon that could cause an upward pressure to $125 and that the long term trend would be ever upward and that downward pressure would provide only temporary dips.

PHILADELPHIA, April 27 /PRNewswire/ --

- Patients' Vision Improved from Detecting Hand Movements to Reading Lines on Eye Chart

In a clinical trial at The Children's Hospital of Philadelphia, researchers from The University of Pennsylvania have used gene therapy to safely restore vision in three young adults with a rare form of congenital blindness. Although the patients have not achieved normal eyesight, the preliminary results set the stage for further studies of an innovative treatment for this and possibly other retinal diseases.

Depending on which variant of the gene CYP1A2 a woman has, a coffee consumption rate of at least two cups a day can either reduce the total risk of developing breast cancer or delay the onset of cancer, according to new research from Lund University and Malmö University in Sweden.

The effect of coffee is related to estrogens - female sex hormones. Certain metabolic products of these hormones are known to be carcinogenic and various components of coffee can alter the metabolism so that a woman acquires a better configuration of various estrogens.

Coffee, of course, contains caffeine, which also hampers the growth of cancer cells.

'Functional foods' are those that provide a health benefit beyond basic nutrition and more people are recognizing that they are an important part of a lifestyle that leads to long-term fitness and even longevity.

Liz Sloan, writing in Food Technology, has identified the top 10 trends in functional foods. The article noted that a majority of Americans, 69 percent, are incorporating foods into a preventative lifestyle, while 27 percent are utilizing food as a treatment to manage a preexisting health condition. One-third of shoppers (36 percent) are trying to reduce the risk of developing a health condition, follow a doctor’s advice (30 percent) or manage/treat a specific condition on their own (25 percent), according to the Food Marketing Institute¹ data.

“Today’s consumers are extremely sophisticated, and they are attracted to functional foods’ ability to help manage health and wellness,” said Institute of Food Technologists(IFT) spokesperson Roger Clemens, PhD. Simply put, Americans are relying heavily on the foods they consume to improve their well-being.

Top 10 Food Trends