While it is well understood that the evolution of new genes leads to adaptations that help species survive, gene loss may also afford a selective advantage.
A group of scientists has investigated this less-studied idea, carrying out the first systematic computational analysis to identify long-established genes that have been lost across millions of years of evolution leading to the human species. Their findings appear in the December 14 issue of PLoS Computational Biology.
Dr. David Haussler and five others in his group at the University of California, Santa Cruz — postdoc Jingchun Zhu, graduate students Zack Sanborn and Craig Lowe, technical projects manager Mark Diekhans, and evolutionary biologist Tom Pringle — are co-authors on the paper.