Surrounding the small islands of genes within the human genome is a vast sea of non-coding DNA. While most of this DNA is junk, some of it is used to help genes turn on and off.
Hopkins researchers write in Genome Research that they have now found that regulatory DNA, which contributes to inherited diseases like Parkinson’s or mental disorders, may be more abundant than we realized.
By conducting an exhaustive analysis of the DNA sequence around a gene required for neuronal development, Andrew McCallion, Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine, and his team found that current computer programs that scan the genome looking for regulatory DNA can miss more than 60 percent of these important DNA regions.