For the first time, scientists have described the transition of the flat, disc-shaped heart field into the primary linear heart tube. The investigations on zebrafish embryos were made by Stefan Rohr and Cécile Otten, members of the research group of Dr. Salim Abdelilah-Seyfried of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany.
Currently, one of the most important areas to explore in developmental biology is how cellular transformation processes lead to the three-dimensional formation (morphogenesis) of organs. A better understanding of these processes is a basic requirement for elucidating congenital malformation of organs.
The heart, for instance, develops in the embryo from a flat disc, the so-called heart field. The tissue of this two-dimensional structure consists of a thin layer of epithelial cells. Similar cells line all inner organs, but also the skin and blood vessels.