A letrozole pill once a week restored fertility in obese, infertile men and led to their partners giving birth to two full-term, healthy babies, according to a new study from Canada. The results will be presented Thursday at the Endocrine Society's 97th annual meeting in San Diego.
"To our knowledge, this is the first report of successful pregnancies with the use of letrozole at this low dose in men," said the study's lead investigator, Lena Salgado, MD, an endocrinology fellow at the Centre Hospitalier de l'Université de Montréal (CHUM).
Letrozole is approved by the Food and Drug Administration for treatment of estrogen receptor positive breast cancer in postmenopausal women and is used "off-label" in infertile women to induce ovulation.