Human-specific variants of four microRNAs may have altered expression levels and gene targets compared to other great apes, according to a study published April 22, 2016 in the open-access journal PLOS ONE by Alicia Gallego from the Institute of Evolutionary Biology, Spain, and colleagues.
MicroRNAs are post-transcriptional gene regulators known to be involved in almost every biological function. They are highly conserved among species and, while some differences exist, the effect of the variations is often unclear. The authors of the present study analysed over 1500 microRNAs to identify variations between humans and other great ape species, including orangutans, gorillas, bonobos and chimpanzees, and the possible effect of these variations on function.