Genetics & Molecular Biology
Since 2014, China has spent $4 billion on advanced agricultural science and is approving new technologies rapidly. Meanwhile, our food science regulatory system remains trapped in the 1980s, paralyzed by environmental lobbyists who buy full-page ads in the New York Times claiming they are "unsure", it just "needs more testing."
A new paper found that the gene-editing technology CRISPR-Cas9 can introduce hundreds of unintended mutations into the genome, important as it starts to move into clinical trials.
CRISPR-Cas9 editing technology—by virtue of its speed and unprecedented precision—has been a boon for scientists trying to understand the role of genes in disease. The technique also has raised hope for more powerful gene therapies that can delete or repair flawed genes, not just add new genes.
Though men and women obviously differ, that has become muddled in the name of equality. Drug reactions are different, obviously one gender gives birth to children.
A new study shows there are still many similarities, but also a whole lot of biological differences not in genes, but in gene expression. Their findings showed that harmful mutations in these particular genes tend to accumulate in the population in relatively high frequencies, and the study explains why. The detailed map of these genes
provides evidence that males and females undergo a sort of separate, but interconnected, evolution.
People with cystic fibrosis suffer repeated lung infections because their airway mucus is too thick and sticky to keep bacteria, viruses, and other pathogens from causing chronic infection. How mucus becomes abnormal in
airways has never been fully understood, but a new study has determined that mucin proteins, which give mucus its gel-like properties, fail to unfold normally in
airways, making airway mucus much more thick and sticky than it would be otherwise.
Cystic fibrosis is a rare genetic disease that affects about 70,000 people worldwide. It occurs when a person has two defective copies of the CFTR gene, which triggers the creation of the CFTR protein. When that protein is mutated, the result is cystic fibrosis.
In case you haven’t been keeping up-to-date with the latest news in the biotechnology regulatory system (and how could you not?), the system is under revision. As part of the new Coordinated Framework the FDA stated it would clarify how it will deal with the hot-button topic of genome editing, and update its guidance documents accordingly. As part of this process the FDA opened a docket on regulations.gov
to receive public comments about the issue. As you might expect, a large majority of the comments have been less than scientific.
They are asking for your evidence-based input. Please give it to them!
Metabolism, the set of processes through which we gain energy from food and produce the biomolecules we need in our body's cells, is universal to life. The biochemical pathways that underpin these processes are highly similar across all organisms and species.
Genetic variants linked to autism spectrum disorders (ASD) contribute to enhanced cognition and are therefore positively selected in spite of the problems they also bring along – new evidence has just been published in PLOS Genetics 
. The problems these genes bring along are the price to pay for relatively rapid evolutionary advancements. It needs a much longer time for further natural selection to smooth the bugs out – this is all obvious, simple science. Another example is the genetic predisposition of Ashkenazim Jews to diseases such as Tai-Sachs, which comes along with their high average verbal IQ, also a relatively recent evolutionary advancement.
With the availability of Arctic Apples
around the corner,
there are a lot of questions swirling about how the browning is suppressed when
the apple is exposed to air. The
browning process has great implications for the value of fruits and fruit
products. This natural discoloration
leads to less consumption of fruit, as well as substantial economic loss and
In what seems like a scene from the movie Groundhog Day, another rat study has come out of the laboratory of Dr. Giles-Eric Séralini, only in this case it is Roundup and not GMOs that are under fire. When I read the title of the paper, “Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide”,
A large-scale international study involving 700,000 participants has revealed 83 genetic variations controlling human height.