Scientists at The Babraham Institute have begun to unpick the complex mechanisms underpinning the development of drug resistant cancers. They have identified a novel target that may help to combat the growing problem of therapy resistant cancers and pave the way for innovative therapeutic approaches. 

Their discovery, reported in the latest edition of the New England Journal of Medicine, centres on the significance of DNA damage for both normal cells and cancer cells. It reveals that a biochemical signalling pathway, that normally ensures damaged cells are diverted towards cellular suicide, is blocked in certain cancers, rendering them resistant to certain types of treatment. 

It was Christmas Eve, 1858 when “people who in the streets, on pathways and in the fields saw a magnificent ball of fire appear, which shone with a brilliant, blinding light and all the colors of the rainbow, obscured the light of the moon and descended majestically from the sky.”  

This was the description of the meteorite that fell that evening, from a report commissioned by Rafael Martínez Fortún, of the town of Molina de Segura in Murcia, whose farm was struck by what is still the largest meteorite recovered in Spain.  Since 1863, it has been exhibited in the National Museum of Natural Sciences.

New research by a Rice University psychologist clearly identifies the parts of the brain involved in the process of choosing appropriate words during speech.

When speaking, a person must select one word from a competing set of words. For example, if the speaker wants to mention a specific animal, he has to single out "dog" from "cat," "horse" and other possibilities. If he wants to describe someone's temperament, he has to choose whether "happy," "sad," "ecstatic" or some other adjective is more appropriate.

Tatiana Schnur, assistant professor of psychology at Rice, wanted to determine whether one particular part of the brain, the left inferior frontal gyrus (LIFG), is necessary for resolving the competition for choosing the correct word.

Researchers at the University of Southern California (USC) have, for the first time in history, derived authentic embryonic stem (ES) cells from rats. This breakthrough finding will enable scientists to create far more effective animal models for the study of a range of human diseases. 

The finding brings scientists much closer to creating "knockout" rats—animals that are genetically modified to lack one or more genes—for biomedical research. By observing what happens to animals when specific genes are removed, researchers can identify the function of the gene and whether it is linked to a specific disease.

Researchers have what they think may be a basic recipe for capturing and maintaining indefinitely the most fundamental of embryonic stem cells from essentially any mammal, including cows, pigs and even humans. Two new studies reported in Cell, show that a cocktail first demonstrated to work in mice earlier this year, which includes inhibitory chemicals, also can be used to successfully isolate embryonic stem cells from rats.

Authentic rat embryonic stem cells had never before been established.

A slow, chronic starvation of the brain as we age appears to be one of the major triggers of a biochemical process that causes some forms of Alzheimer's disease.

A new study from Northwestern University's Feinberg School of Medicine has found when the brain doesn't get enough sugar glucose -- as might occur when cardiovascular disease restricts blood flow in arteries to the brain -- a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer's.