A new study in The Journal of Clinical Investigation (JCI) found that preventing weight gain, obesity, and ultimately diabetes could be as simple as keeping a nuclear receptor, PPARgamma, from being activated in a small part of the brain.

When researchers blocked the effects of PPARgamma in a small number of brain cells in mice, the animals ate less and became resistant to a high-fat diet.

Proopiomelanocortin (POMC) neurons are found in the hypothalamus and regulate food intake. When activated, these neurons cause a feeling of fullness and curb appetite. PPARgamma regulates the activation of these neurons.

Scientists have recently gathered some of the strongest evidence to date to explain what makes the sun's outer atmosphere so much hotter than its surface. The new observations of the small-scale extremely hot temperatures are consistent with only one current theory - nanoflares – a constant peppering of impulsive bursts of heating, none of which can be individually detected, provide the mysterious extra heat.

In the world we commonly perceive around us, it takes only a slight disturbance for a pencil standing on its tip to fall in one direction or another, but in the quantum world it is possible in principle for particles of a system to fall both left and right at the same time.

Differentiating this “and” state – the quantum entanglement of particles – from the classical “or” is an experimental challenge. Scientists have now devised a  quantum metrology method that enables entanglement verification for states of large atomic systems.

Dietary capsaicin, the active ingredient in chili peppers, produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors, finds a study in The Journal of Clinical Investigation.

More than 10,000 reptile species have been recorded into the Reptile Database, a web-based catalog of all living reptile species and classification, making the reptile species among the most diverse vertebrate groups in the world, alongside bird and fish species, and likely the largest known.

Experts projected that 2014 would mark the year that reptiles would become the most diverse vertebrate group in the world. Reptiles include snakes, lizards, turtles, crocodiles, tuataras and amphisbaenians.

A paper in The Journal of Clinical Investigation helps explain why brain tumors occur more often in males and frequently are more harmful than similar tumors in females.

Glioblastomas, the most common malignant brain tumors, are diagnosed twice as often in males, who suffer greater cognitive impairments than females and do not survive as long. The researchers found that retinoblastoma protein (RB), a protein known to reduce cancer risk, is significantly less active in male brain cells than in female brain cells.