About Manonmani M.Sc, Ph.D in Biochemistry. Postdoctoral Fellow (Univ. of Texas Health Sci. Ctr. at SanAntonio.). Working on Prostate Cancer prevention and treatment using natural drugs through molecular targeted approaches. Publications: 1.Manonmani Ganapathy, Rita Ghosh, jp Xiaoping Zhang, Roble Bedolla, John Schoolfield, I-Tien Yeh, Dean A Troyer, Aria F Olumi and Addanki P Kumar. Involvement of FLIP in 2-methoxyestradiol induced tumor regression in transgenic adenocarcinoma of mouse prostate (TRAMP) model- Clinical Cancer Research, (accepted 14th November 2008). 2. Rita Ghosh, Manonmani Ganapathy, William L Alworth, E Chan, and Addanki P Kumar. Combination of 2-Methoxyestradiol (2-ME2) and Eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. J. Steroid Biochem. and mol. Biol. ( Article in Press doi:10.1016/j.jsbmb.2008.11.002, November 21st. 2008) 3. Addanki P Kumar, Shylesh Bhaskaran, Manonmani Ganapathy, Katherine Crosby, Michael D Davies, Peter Kochunov, John Schoolfield, I-Tien Yeh, Dean A Troyer and Rita Ghosh. Akt/CREB/CyclinD1 network: a novel target for prostate cancer inhibition mediated by NexrutineÀ®, a phellodendron amurense bark extract. Clin.Cancer Res. 2007, 13(9): 2784-94. 4. Manonmani G, Bhavapriya V, Kalpana S, Govindasamy S, Apparanantham T. Antioxidant activity of Cassia fistula flowers in alloxan induced diabetic rats. Journal of Ethnopharmacol. 2005, 97(1): 39-42. 5. Manonmani G, Anbarasi K, Balakrishna K,Veluchamy G and Shyamala Devi C.S. Effect of Terminalia Arjuna on the antioxidant defence system in alloxan induced diabetes in rats. Biomedicine. 2002, 22(3 and 4): 52-61. Abstracts: 1.Manonmani Ganapathy, Rita Ghosh, Xiaoping Z, Aria F Olumi, Pratap Kumar A. Transcriptional regulation of FLIP as a therapeutic target in prostate cancer. Proceedings of 99th annual meetings of American Association of Cancer Research, Apr12th-16th, 2008, San Dieago, CA (Abstract #4424). 2.Rita Ghosh, Manonmani Ganapathy, Muralimanoharan Sribalasubashini, Heather Graham, Paul Rivas, Xie Jianping, Craig Robson and Addank P. Kumar. Targeting cell survival and apoptotic signaling pathways for prostate cancer management. Proceedings of 8th International Conference of Anticancer Research, 17-22nd October 2008, Kos, Greece. (Abstract # 368) 3.Ghosh R, Ganapathy M, Chakradhar V, Rivas P, Kunnumakkara AB, Aggarwal BA, Thompson IM and Kumar AP. Targeting Akt/CREB and NFkB network for prevention of prostate tumors in preclinical animal model: Use of Nexrutine, a Phellodendron amurense bark extract. Proceedings of Society for Translational Cancer Research on Natural products and Cancer, December 9th-12th 2007, Lonavala, Mumbai, India. (Abstract #MS22). 4. Manonmani G, Xiaoping Z, Aria F Olumi, Rita Ghosh, Pratap Kumar A. Anti-proliferative Activity of 2-Methoxyestradiol (2-ME) in Prostate Cancer Cells through Induction of Apoptosis. Proceedings of 98th Annual meeting of American Association of Cancer Research, April 14-18th 2007, Los Angeles, CA. (Abstract # 5035). 5.Manonmani Ganapathy, K.Balakrishna, G.Veluchamy and C.S.Shyamala Devi. Anti-diabetic effect of Terminalia arjuna (Combretaceae) - a traditional herb in experimental diabetes. Proceedings of Fundamental Chemical and Biological sciences, May 21-24th 2001, National University of Singapore, Singapore. (Poster # 21). 6. Ilavarsan R, Mohideen S, Vijayalakshmi M, Manonmani G. Hepatoprective effect of Cassia angustifolia Vahl. Indian J.Pharm.Sci. 2001, 63(6): 504-507.

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