FORT PIERCE, FL - In citrus fruit, the color of the peel is a major factor in consumer selection; fresh oranges with a dark orange peel are favored. In order to appeal to consumer preferences, citrus that is picked when it hasn't reached peak color is often "degreened", and then may be treated with an emulsion containing Citrus Red No.2 (CR2) to improve peel color. A new study reveals three food grade colorants that are promising natural alternatives to CR2.

An international collaboration between scientists in Sweden, Russia, and the United States has resulted in the successful engineering of new diaphragm tissue in rats using a mixture of stem cells and a 3D scaffold. When transplanted, it has regrown with the same complex mechanical properties of diaphragm muscle. The study is published in the journal Biomaterials, and offers hope of a cure for a common birth defect and possible future heart muscle repairs.

What differentiates complex fluids from mere fluids? What makes them unique is that they are neither solid nor liquid. Among such complex fluids are foams. They are used as a model to understand the mechanisms underlying complex fluids flow. Now, a team of French physicists has gained new insights into predicting how complex fluids react under stretching conditions due to the interplay between elasticity, plasticity and flow. These findings were recently published in EPJ E by Benjamin Dollet and Claire Bocher from the Rennes Institute of Physics, in Brittany, France. Ultimately, potential applications include the design of new, optimised acoustic insulators based on liquid forms, or the mitigation of blast waves caused by explosions.

Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences and The Wyss Institute for Biologically Inspired Engineering have developed a new, more precise way to control the differentiation of stem cells into bone cells. This new technique has promising applications in the realm of bone regeneration, growth and healing. The research, led by David Mooney, the Robert P. Pinkas Family Professor of Bioengineering at SEAS, was published in Nature Materials.

All the stars in the sky will eventually die - and some will really go out with a bang.

When a dying star goes supernova, it explodes with such ferocity that it outshines the entire galaxy in which it lived, spewing material and energy across unimaginable distances at near-light speed.

In some cases, these cosmic cataclysms defy expectations, blasting not symmetrically in all directions - as an exploding firework might - but instead launching two narrow beams, known as jets, in opposite directions.

Understanding how these jets are created is a vexing challenge, but an international research team has recently employed powerful computer simulations to sleuth out some answers.

The examination room computer promises safer, more efficient and more effective patient care. But exam room computing is challenging and there is growing evidence that it can be a threat to patient safety and detrimental to good relationships and health outcomes, according to a commentary in JAMA Internal Medicine.

Regenstrief Institute sociologist Richard Frankel, Ph.D. presents POISED, a model he has devised for developing and reinforcing good exam room computer-use by physicians.

A new study by UC San Francisco scientists shows that the proportion of normal cells, especially immune cells, intermixed with cancerous cells in a given tissue sample may significantly skew the results of genetic analyses and other tests performed both by researchers and by physicians selecting precision therapies.

Cells dynamically respond to environmental signals by turning appropriate sets of genes on or off. The "control system" that determines which genes need to be expressed at what time depends primarily on the interactions between transcription factor proteins (TFs) and the regulatory DNA sequence. This system is highly complex--especially in cells of multicellular organisms--as correct combinations of TF molecules need to bind specific sites on the DNA. Surprisingly, while multicellular organisms need to regulate more genes compared to bacterial cells, their TFs are less specific and bind promiscuously on many genomic locations, including unsuitable ones. So how can TFs reliably turn on the correct gene, while avoiding erroneously turning on the others?

PHILADELPHIA, December 4, 2015 - Immune dysfunction is increasingly recognized as a cause of drug-resistant epilepsy but how or why the immune system attacks nerve cells - and the consequences on seizure control - are not well understood. Two studies presented at the American Epilepsy Society's (AES) 69th Annual Meeting explore how different types of autoimmune response elicit markedly different responses in patients with drug-resistant epilepsy.

A study by researchers from the University of Toronto and Western University (abstract 3.153) offers evidence that not all autoimmune epilepsies are equal, at least in terms of prognosis and response to treatment.