Chemotherapy, the treatment of cancer using chemotherapeutic agents such as cytotoxic antineoplastic drugs, is one of the primary treatments for cancer - but it has drawbacks. Some of the most disturbing findings of recent studies of cancer survivors is the apparent prevalence of chemotherapy-associated adverse neurological effects, including vascular complications, seizures, mood disorders, cognitive dysfunctions, and peripheral neuropathies.
In addition, chemotherapy triggers changes in ion channels on dorsal root ganglia and dorsal horn neurons that generate secondary changes resulting in neuropathic pains.