Today's industrial yeast strains are used to make beer, wine, bread, biofuels, and more, but their evolutionary history is not well studied. In a Cell paper publishing September 8, researchers describe a family tree of these microbes with an emphasis on beer yeast. The resulting genetic relationships reveal clues as to when yeast was first domesticated, who the earliest beer brewers were, and how humans have shaped this organism's development.

"The flavor of the beer we drink largely depends on yeast," explains Kevin Verstrepen, a yeast geneticist at the University of Leuven and VIB in Belgium. "We're drinking the best beers now because ancient brewers were smart enough to start breeding yeast before they knew what they were doing. It was really an art."

Up until now, scientists had only recognized a single species of giraffe made up of several subspecies. But, according to the most inclusive genetic analysis of giraffe relationships to date, giraffes actually aren't one species, but four. For comparison, the genetic differences among giraffe species are at least as great as those between polar and brown bears.

The unexpected findings reported in the Cell Press journal Current Biology on September 8 highlight the urgent need for further study of the four genetically isolated species and for greater conservation efforts for the world's tallest mammal, the researchers say.

Ants visually track the motion of objects as they move through their environment in order to determine the distance they have traveled, a new study reports. Such tracking, called optic flow, has been observed in a number of insects but was thought to be used only minimally by ants. Now, results by Sarah Elisabeth Pfeffer and Matthias Wittlinger suggest that certain ants can rely solely on optic flow to find their way back to their nest when lost. Here, they studied Cataglyphis bicolor desert ants, which exhibit unique behaviors; namely, experienced forager ants carry interior nest workers, who are much less familiar with the outdoor environment, between different nest sites.

Scientists have shown that a two-pronged antibody can counteract the unique immune-evasion mechanism that filoviruses like Ebola have evolved. This is a critical step on the road to developing treatments that protect broadly against ebolaviruses, for which there remains an urgent need. Filoviruses including Ebola have an unusual route into the host cell; they access the inside of cells through tiny transport vesicles, or endosomes, where they interact with a specific host-cell receptor called NPC1, and then become unmasked. In effect, this two-step pathway acts as a shield -- hiding the virus from the immune system and hindering the potency of anti-viral therapies.

Researchers have developed a large culturing device to track the evolution of bacteria as they mutate in the presence of antibiotics, revealing that, surprisingly, the fittest mutants were not those most likely to infiltrate higher antibiotic concentrations. Instead, bacteria "behind" the very fittest on the growth plate became capable of surviving at highest antibiotic concentrations. The results provide important insights into the evolutionary patterns and mechanisms that drive bacteria's success in overcoming antibiotics, a phenomenon that threatens human health worldwide.

The human microbiota -- the entirety of bacteria which live e.g. on the skin or in the intestinal tract -- has an unknown influence on health. A team led by Prof. Tilo Biedermann, the director of the Clinic for Dermatology and Allergology at Rechts der Isar Hospital, examined the role microbiota plays in the digestive system in the case of food allergies and found that they may also play a role in determining the strength of anaphylactic reactions to food allergens. 

New Orleans, LA - Dr. Robert Zura, the Robert D'Ambrosia Professor and Head of Orthopaedic Surgery at LSU Health New Orleans School of Medicine, was part of a research team that identified risk factors which may help orthopaedic surgeons better predict a serious complication of bone fractures. Fracture nonunion may be increasing as more patients survive serious fractures. The paper was published September 7, 2016, in the Online First section of JAMA Surgery, available at http://archsurg.jamanetwork.com/article.aspx?articleid=2547685.

RIVERSIDE, Calif. -- Released on Sept. 4, 1957, Ford dubbed its Edsel "the car of the future." It was designed to stand out, but most people didn't like the way it looked. Add "ugly" to a laundry list of problems from poor performance to a high price tag and the car tanked--its only lasting legacy being a lesson in how not to develop a product.

But what does the ideal car look like?

University of California, Riverside professor Subramanian "Bala" Balachander and his collaborators explored that question in a study that is forthcoming in the Journal of Marketing. Balachander is the Albert O. Steffey Chair and Professor of Marketing at UCR's School of Business.

Medication is an important part of treatment for many patients with major depressive disorder, but the transition to antidepressants isn't always smooth.

It can take six weeks for a person to respond to pharmacotherapy. And with remission rates at about only one-third, the majority of patients with depression could also benefit from better overall response to medication.

Researchers at the University of Michigan who specialize in both psychiatry and sleep medicine found a potential way to help. A precise sleep schedule could affect antidepressant remission rates and response time, researchers found. But not in the way they thought.

A new car is a big expense for anyone -- but it will cost some people more than others, even at the same dealership.

A new U of T study, which is the first of its kind to reliably show large differences in the price paid for a new car, reveals that age and even in some cases gender can be a factor.

"We were surprised by the magnitude of the difference in how much people paid for an identical car that was bought in the same month in even the same city," says Ambarish Chandra, Assistant Professor of Business Economics in U of T Scarborough's Department of Management and the Rotman School of Management.