A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer's disease suggests a new focus for research into the causes of the disease.
Previous research has revolved around the idea that accumulation in the brain of a small, sticky protein fragment -- amyloid beta -- causes Alzheimer's disease.
However, there is growing concern among researchers that this idea is not rapidly advancing global understanding of the disease or leading to successful treatments.
The University of Adelaide scientists, in collaboration with researchers from a number of other Australian universities, say their analysis points to a new theory about how mutations of a particular gene, PSEN1, can trigger early onset Alzheimer's disease.