For several types of cancer, persistently high levels of the soluble factor TGF-beta in the blood after surgery, chemotherapy, or radiation therapy correlate with increased risk of early metastasis and a poor prognosis.

Researchers at the University of Pennsylvania School of Medicine & School of Engineering and Applied Science have discovered a better way to deliver drugs to tumors. By using a cylindrical-shaped carrier they were able sustain delivery of the anticancer drug paclitaxel to an animal model of lung cancer ten times longer than that delivered on spherical-shaped carriers. These findings have implications for drug delivery as well as for better understanding cylinder-shaped viruses like Ebola and H5N1 influenza.

In findings the authors called "unexpected and striking," researchers found that a new regulating messenger IP4, a small soluble molecule, augments the binding of three different PH domain proteins to one of the most commonly recognized membrane lipids, PIP3. The study also showed that inhibiting production of IP4 can result in reduced protein binding to membranes and reduced activation of key signaling molecules in developing T cells, leading to a block of T cell maturation and to severe immunodeficiency in animal models.

Researchers have demonstrated a prototype nanometer-scale generator that produces continuous direct-current electricity by harvesting mechanical energy from such environmental sources as ultrasonic waves, mechanical vibration or blood flow.

Based on arrays of vertically-aligned zinc oxide nanowires that move inside a novel “zig-zag” plate electrode, the nanogenerators could provide a new way to power nanoscale devices without batteries or other external power sources.

Scientists from the universities of Exeter and Cambridge have turned a textbook example of sexual selection on its head and shown that females may be more astute at choosing a mate than previously thought.

New research, funded by the Leverhulme Trust and published in Current Biology, shows that differences in the lengths of the long tail feathers possessed by male barn swallows are more about aerodynamics than being attractive. Female barn swallows favour mates with longer tails and the prominent male tail ‘streamers’ that extend beyond the tail were cited by Darwin as evidence of sexual selection. Now for the first time, scientists have tested this assumption and found that these ‘ornaments’ are in fact linked to natural selection.

I grew up in the prairies and one of my favourite ways to relieve the boredom of long summer road trips was to examine the different bugs splattered on the windshield. I would try to figure out which bug each splatter was and I was fascinated by the ways some left green smears or bright, thick, yellow splats. It made me wonder why animals have different colours of blood and how many different colours there are.

In a galaxy far, far away, a massive star suffered a nasty double whammy. On Oct. 20, 2004, Japanese amateur astronomer Koichi Itagaki saw the star let loose an outburst so bright that it was initially mistaken for a supernova. The star survived, but for only two years. On Oct. 11, 2006, professional and amateur astronomers witnessed the star actually blowing itself to smithereens as Supernova 2006jc.

As the ancient Greeks were placing the last few stones on the magnificent theater at Epidaurus in the fourth century B.C., they couldn’t have known that they had unwittingly created a sophisticated acoustic filter. But when audiences in the back row were able to hear music and voices with amazing clarity (well before any theater had the luxury of a sound system), the Greeks must have known that they had done something very right because they made many attempts to duplicate Epidaurus’ design, but never with the same success.

New research by Iowa State University psychologists says it provides more concrete evidence of the adverse effects of violent video game exposure on the behavior of children and adolescents. 

Distinguished Professor of Psychology Craig Anderson, Assistant Professor of Psychology Douglas Gentile, and doctoral student Katherine Buckley share the results of three new studies in a book, "Violent Video Game Effects on Children and Adolescents" (Oxford University Press, 2007). It says it is the first book to unite empirical research and public policy related to violent video games.

Geophysicists at the University of Rochester announce in today’s issue of Nature that the Earth’s magnetic field was nearly as strong 3.2 billion years ago as it is today.

The findings, which are contrary to previous studies, suggest that even in its earliest stages the Earth was already well protected from the solar wind, which can strip away a planet’s atmosphere and bathe its surface in lethal radiation.