Researchers in Hong Kong have miniaturized technology needed to perform the versatile polymerase chain reaction (PCR) — widely used in criminal investigations, disease diagnosis, and a range of other key applications.
Published in Analytical Chemistry, they report development of a long-sought PCR microchip that could permit use of PCR at crime scenes, in doctors’ offices, and other out-of-lab locations.
I-Ming Hsing and colleagues note that PCR works like a biological copy machine, transforming a few wisps of DNA into billions of copies. However, existing PCR machines are so big and complex that they can be used only in laboratories.