Clinical Research

Contrary to current clinical belief, regular caffeine consumption does not lead to extra heartbeats that have been linked to heart-or stroke-related morbidity and mortality.

The study, which measured the chronic consumption of caffeinated products over a 12-month period, rather than acute consumption, appears in the January 2016 issue of the Journal of the American Heart Association. The authors say it is the largest to date to have evaluated dietary patterns in relation to extra heartbeats.

There is good news in the annual data report from the United States Renal Data System, coordinating center based at the University of Michigan Kidney Epidemiology and Cost Center, in partnership with Arbor Research Collaborative for Health. 

A team of academic cancer specialists has a way to lower drug discovery costs without politicians killing off one of the few remaining non-service industries in America: do less research.

Currently, early cancer drug studies involve extra biopsies solely for the purpose of trying to understand the pharmacodynamics -- what the drug does to the tumor -- they are often mandatory in government-sponsored phase 1 clinical trials because the belief is that computer and cellular models won't be accurate enough. This obviously increases the time and costs of development and a team says that this costly process has had no impact on subsequent drug development or how physicians use these new drugs to treat future patients.

Scientists revealed mayor players in the severe muscle damage caused by sepsis, or septicemia, which explains why many patients suffer debilitating muscle impairment long-term after recovery. They propose a therapeutic approach based on mesenchymal stem cell transplantation, which has produced encouraging results and has proved successful in restoring muscle capacity in animals.

The acromio-clavicular joint is located at the top of the shoulder, between the collarbone and top of the shoulder blade. The AC joint is most commonly injured during sports, but can also be caused by motor vehicle accidents or falls. This dislocation is one of the most common shoulder injuries orthopedic surgeons treat.

For minor AC joint dislocations, surgeons often suggest patients wear a sling for a few weeks and undergo physiotherapy rather than undergo surgery using a plate and screws. Severe dislocations are often treated with surgery but new research finds that patients who opt for non-surgical treatment typically experience fewer complications and return to work sooner. 

Children with the genetic disorder tuberous sclerosis complex (TSC) often need epilepsy surgery for severe, uncontrollable seizures and a new study finds that seizure control is improved for patients undergoing more extensive surgery.

Seizures occurring in TSC are related to development of brain tumors, known as "tubers," that develop in this disorder. But the new study by Dr. Aria Fallah of Miami Children's Hospital and colleagues finds better outcomes when surgery includes the entire "epileptogenic zone" from which seizures are originating--not just the tuber itself.

Epilepsy Surgery for Tuberous Sclerosis--Study from Six Specialty Centers

Mesoamerican Nephropathy, a mysterious kidney disease that has killed over 20,000 people in Central America, most of them sugar cane workers, may be caused by chronic, severe dehydration linked to global climate change, according to a new study by Richard J. Johnson, MD, of the University of Colorado Anschutz Medical Campus.

The Mesoamerican Nephropathy epidemic was first described in 2002. It's most prevalent among manual laborers on sugar cane plantations in the hotter, lower altitudes of Central America's Pacific coast. The disease has also been reported among farmworkers, miners, fishermen and construction and transportation workers in the region.

In this age of the 24-hour news cycle, instant access to all information everywhere, PubMed, LinkedIn, Facebook, Twitter and hundreds of other ways to glean and share knowledge beyond the traditional stack of printed journals delivered to their door, physicians continue to struggle to arm themselves with the most effective therapies.

Fast access to information may result in practice change; however, subsequent data may disprove effectiveness and require even more practice change. The cycle may continue over several years and several studies, with the potential for missed information growing with each practice-change decision.

Since the Food and Drug Administration (FDA) cautioned against using a minimally invasive method to treat fibroid tumors called power morcellation, there was a nearly quarter increase in hospital readmissions and 27 percent increase in major postoperative complications after hysterectomies in Michigan, a new University of Michigan study says.

After the first FDA safety communication in April 2014, the percent of women receiving minimally invasive hysterectomies in a large Michigan database also went down by an absolute 1.7 percent decrease.

The findings appear in the American Journal of Obstetrics&Gynecology.

When a jogger sets out on his evening run, the active movements of his arms and legs are accompanied by involuntary changes in the position of the head relative to the rest of the body. Yet the jogger does not experience feelings of dizziness like those induced in the passive riders of a rollercoaster, who have no control over the abrupt dips and swoops to which they are exposed.

The reason for the difference lies in the vestibular organ (VO) located in the inner ear, which controls balance and posture. The VO senses ongoing self-motion and ensures that, while running, the jogger unconsciously compensates for the accompanying changes in the orientation of the head.