On the 25th anniversary of the first scientific article linking a retrovirus to AIDS, Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases, reflects on his experience treating and studying HIV/AIDS for the past quarter century.
Outlining the peaks and valleys of the scientific community’s journey so far, Dr. Fauci writes, “…we must learn from our mis-steps, build on our successes in treatment and prevention, and renew our commitment to developing the truly transforming tools that will one day put this scourge behind us.”
From the outset, AIDS was clearly more menacing than any other novel disease Dr. Fauci and his colleagues had previously encountered, he writes. The period when clinicians lacked the ability to diagnose and treat AIDS was the bleakest of his career. The discovery that HIV causes AIDS stimulated a burst of progress in both the clinic and the laboratory. But the 1987 debut of the first effective drug against HIV, zidovudine (AZT), generated excessive optimism, Dr. Fauci reflects, as the virus quickly and predictably developed drug resistance.