Investigators at the Stanford University School of Medicine and their collaborators at three other institutions have identified a novel compound that appears to exhibit painkilling power comparable to morphine but lacks that drug's most lethal property: respiratory suppression, which results in some 30,000 drug overdose deaths annually in the United States.
"This promising drug candidate was identified through an intensively cross-disciplinary, cross-continental combination of computer-based drug screening, medicinal chemistry, intuition and extensive preclinical testing," said Brian Kobilka, MD, professor of molecular and cellular physiology, and one of the senior investigators involved in the research.