In their search for the cellular and molecular causes of multiple sclerosis, an Italian-German research team has identified a subgroup of protective immune cells (suppressor cells) which are strikingly reduced in number in patients with this nervous system disorder.
These suppressor cells are characterized by a specific surface marker, called CD39, and degrade ATP, an energy carrier released from damaged tissues. By this means, suppressor cells appear to be able to curb inflammation occurring in the central nervous system in the course of the disease.
With CD39, Dr. Giovanna Borsellino (Laboratory for Neuroimmunology of the Fondazione Santa Lucia in Rome, Italy) in collaboration with Dr. Olaf Rötzschke and Dr.