Not 10 years ago, most doctors agreed that estrogen supplements for post-menopausal women reduced the risk of heart attacks. Millions were paying extravagantly for “hormone replacement therapy”, and drug companies were making a killing. However, a comprehensive study conducted by the Women’s Health Initiative was stopped early, in 2002, because the dangers to healthy women taking estrogen were deemed excessive. Estrogen therapy, it turned out, actually increased the risk of heart attack, strokes, and breast cancer. The medical community was shocked. The Annals of Internal Medicine ran an editorial “How Could We Have Been So Wrong?” The National Institutes of Health hosted a special seminar on “methodology” and “medical evidence”.