Antibodies and their derivatives can protect plants and humans against viruses but members of this class of drugs are usually highly specific against components of a particular virus, and mutations in the virus that change these components can make them ineffective.
But a mini-antibody called 3D8 scFv can chew up viral DNA and RNA regardless of specific sequences and protect mammalian cells and genetically manipulated mice against different viruses.
Sukchan Lee, from Sungkyunkwan University in Korea, and colleagues had previously discovered that 3D8 has both DNase and RNase activity (that is, it can degrade both), and that it can inhibit viruses under certain circumstances. In this study, they genetically manipulated cells and mice to produce 3D8.