FINDINGS

Using the landmark Framingham Heart Study to assess how physical activity affects the size of the brain and one's risk for developing dementia, UCLA researchers found an association between low physical activity and a higher risk for dementia in older individuals. This suggests that regular physical activity for older adults could lead to higher brain volumes and a reduced risk for developing dementia.

The researchers found that physical activity particularly affected the size of the hippocampus, which is the part of the brain controlling short-term memory. Also, the protective effect of regular physical activity against dementia was strongest in people age 75 and older.

BACKGROUND

A new review examines the potential of antioxidant approaches for the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis.

Certain compounds that are involved in oxidative stress look like promising therapeutic targets. For example, researchers are investigating the potential of increasing antioxidant capacity by targeting what's known as the Nrf2 pathway, as well as developing inhibitors of NADPH oxidases, which are key sources of reactive oxygen species. Other potential strategies for limiting oxidative stress in neurodegenerative diseases include reducing the production of nitric oxide, or preventing mitochondrial dysfunction.

Consistent with previous reports, poor sleep quality was linked with joint pain in a recent Arthritis Care & Research study of the general population, but the study found no association between obstructive sleep apnea and pain or daytime sleepiness. This lack of association between pain and sleep apnea is surprising given the established link between pain and poor sleep quality.

Additional studies are needed to determine whether the relationship between pain and sleep apnea is different depending on the cause of sleep apnea. Furthermore, the mechanisms behind the different relationship between pain and sleep apnea compared with that of pain and sleep quality remain unclear and should be investigated.

Archaeological sites speak about the everyday lives of people in other times. Yet knowing how to interpret this reality does not tend to be straightforward. We know that Palaeolithic societies lived on hunting and gathering, but the bones found in prehistoric settlements are not always the food leftovers of the societies that lived in them. Or they are not exclusively that.

Farmers are doing a lot more than just feeding the world, they are also offsetting tropical forests declines, capturing nearly 0.75 giga-tons of carbon dioxide every year ---but global warming estimates never account for that. 

In a recent study of girls and women diagnosed with at least one autoimmune disease, vaccination against human papillomavirus (HPV) did not increase the risk of developing another autoimmune disease. In fact, being vaccinated was associated with a slightly reduced risk compared with not being vaccinated.

The study included all 70,265 girls and women between 10 and 30 years of age in Sweden in 2006 to 2010 diagnosed with an autoimmune disease.

Dr. Lisen Arnheim-Dahlstrom, senior author of the Journal of Internal Medicine study, noted that individuals with autoimmune disease are vulnerable to vaccine-preventable diseases.