Scientists at the University of Southampton have discovered a potential and novel way of preventing asthma at the origin of the disease, a finding that could challenge the current understanding of the condition.

The research, published in The Journal of Clinical Investigation (JCI) Insight, analysed the impact of the gene ADAM33, which is associated with the development of asthma.

ADAM33 makes an enzyme, which is attached to cells in the airway muscles. When the enzyme loses its anchor to the cell surface, it is prone to going rogue around the lung causing poorer lung function in people who have asthma.

For the first time Japanese researchers discovered that the extracellular domain of taste receptor proteins undergoes a change in structure by binding together taste substances. This structure change is thought to transmit the extracellular binding of taste substances to taste cells. The findings will contribute to our basic understanding of taste mechanisms and the development of a new taste evaluation system that makes use of the screening and detection of taste receptor structure changes.

The Large Underground Xenon (LUX) dark matter experiment, which operates beneath a mile of rock at the Sanford Underground Research Facility in the Black Hills of South Dakota, has completed its search for the missing matter of the universe yielding no trace of a dark matter particle. 

LUX's extreme sensitivity makes the team confident that if dark matter particles had interacted with the LUX's xenon target, the detector would almost certainly have seen them. In a 'what you don't find is important also' sense, these new limits on dark matter detection will allow scientists to eliminate many potential models for dark matter particles. 

Ratings of our own abilities are strongly influenced by the performance of others, according to a study published July 20 in Neuron. Interacting with high performers makes us feel more capable in cooperative team settings, but less competent in competitive situations. Moreover, the degree of "self-other-mergence" is associated with activity in a brain region previously implicated in theory of mind--the ability to understand the mental states of oneself and others.

People with a variant copy of the TREM2 gene have an increased risk of developing Alzheimer's disease, but researchers are only beginning to understand why.

A Genentech study has uncovered details of how a type of immune cell helps the brain get rid of the tiny amyloid-beta aggregates that can clump together to form the plaques characteristic of Alzheimer's. The researchers, reporting July 20 in Neuron, found that TREM2 mutations can derail the immune cell's plaque-clearing activity, as can two other genes already known to increase a person's risk for Alzheimer's: APOE and APOJ (known as clusterin).

"I think we're only scratching the surface of what TREM2 does," said Morgan Sheng, a senior author of the paper and Vice-President of Neuroscience at Genentech.

Scampering across the salt pans of Tunisia on their spindly legs, desert ants (Cataglyphis fortis) have a single-minded mission: locate food and get it back to the nest. Normally, individual raiders bear a tasty morsel in their mandibles and navigate home along the most direct return route, regardless of how tortuous the outbound journey was. However, their determination is often tested to the extreme when the robust animals stumble upon a particularly large piece of food - such as a dead spider or locust. Undaunted, the scavenger simply drags the feast backwards: 'They are really awesome', chuckles Matthias Wittlinger from the University of Ulm, Germany. However, how do the insects navigate while reversing? 'All the cues are from the other direction', says Wittlinger.