Applying topical retinol to the skin appears to improve the wrinkles associated with natural aging and may help to promote the production of skin-building compounds, according to a report in the May issue of Archives of Dermatology.

The wrinkles and brown spots associated with aging appear first and most prominently on skin exposed to the sun, according to background information in the article.

The use of peginterferon alone, or in combination with ribavirin, points to a cure for hepatitis C, the leading cause of cirrhosis, liver cancer and the need for liver transplant, a Virginia Commonwealth University researcher said today.

Mitchell Shiffman, M.D., professor in the VCU School of Medicine, and chief of hepatology and medical director of the Liver Transplant Program at the Virginia Commonwealth University Medical Center, is one of the lead investigators in the study, which was presented at the 38th annual Digestive Disease Week conference in Washington, D.C. VCU was among about 40 sites worldwide studying pegylated interferon alfa-2a, manufactured by Roche Inc.

Researchers at Boston University School of Medicine (BUSM) and McLean Hospital have found that practicing yoga may elevate brain gamma-aminobutyric (GABA) levels, the brain's primary inhibitory neurotransmitter. The findings suggest that the practice of yoga be explored as a possible treatment for depression and anxiety, disorders associated with low GABA levels.

The World Health Organization reports that mental illness makes up to fifteen percent of disease in the world. Depression and anxiety disorders both contribute to this burden and are associated with low GABA levels. Currently, these disorders have been successfully treated with pharmaceutical agents designed to increase GABA levels.

New research into urologic conditions – such as erectile dysfunction – indicate that these disorders could be associated with or precursors to more serious conditions, and suggest a need for practitioners to view these diseases in the greater context of total health as opposed to isolated disorders.

Here are some new studies showing links between ED and other diseases:

ENDOTHELIAL DYSFUNCTION AND OXIDATIVE STRESS ASSOCIATED WITH THE METABOLIC SYNDROME CAN BE REVERSED BY A CHRONIC TREATMENT WITH SILDENAFIL

Researchers at Harvard University and Princeton University have made a crucial step toward building biological computers, tiny implantable devices that can monitor the activities and characteristics of human cells. The information provided by these "molecular doctors," constructed entirely of DNA, RNA, and proteins, could eventually revolutionize medicine by directing therapies only to diseased cells or tissues.

Tissue engineering and regenerative medicine offer future patients greater options for treatment and cure of a wide array of urologic conditions, and controversies surrounding the sources of stem cells as well as their use have fueled increased research.

Here are highlights from the latest research:

ISOLATION OF HUMAN SPERMATOGONIAL STEM CELLS FROM TESTICULAR PARENCHYMA AND DIFFERENTIATION TOWARDS DIFFERENT TISSUES OF THE THREE HUMAN GERM LAYERS