The use of targeted nanoparticles offers promising techniques for cancer treatment. Researchers in the laboratory of Mark E. Davis at the California Institute of Technology have been using small interfering RNA (siRNA), sometimes known as silencing RNA, to "silence" specific genes that are implicated in certain malignancies.

One of the primary challenges associated with this type of therapy is delivering the therapeutic agent into the body and then to the tumor in a safe and effective manner. By using targeted nanoparticles, researchers have demonstrated that systemically delivered siRNA can slow the growth of tumors in mice without eliciting the toxicities often associated with cancer therapies.

Approximately ten million American adults have problems controlling their bladders. Bladder disease affects both men and women and can include incontinence or interstitial cystitis, a chronic inflammatory condition that causes frequent, urgent and painful urination and pelvic discomfort.

Herbal agents could be used to treat inflammatory bladder diseases, according to a preliminary study that looked at the ability of green tea to protect bladder cells from inflammation. The University of Pittsburgh School of Medicine study, found that components of green tea protected bladder cells from damage in culture.

The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells. In the first method, developed at the University of Miami, researchers show how magnetic nanoparticles (MNPs) may be used to create mechanical tension that stimulates the growth and elongation of axons of the central nervous system neurons. The second method from the University of California, Berkeley uses aligned nanofibers containing one or more growth factors to provide a bioactive matrix where nerve cells can regrow.

People with obstructive sleep apnea have a markedly increased risk of severe motor vehicle crashes involving personal injury, according to a study presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20.

The study of 800 people with sleep apnea and 800 without the nighttime breathing disorder found that patients with sleep apnea were twice as likely as people without sleep apnea to have a car crash, and three to five times as likely to have a serious crash involving personal injury. Overall, the sleep apnea group had a total of 250 crashes over three years, compared with 123 crashes in the group without sleep apnea.

Northwestern University researchers have discovered that a recently identified genetic marker for prostate cancer is linked to a highly aggressive form of the disease.

These findings ultimately will aid the development of a simple blood test to predict who is susceptible to this aggressive cancer, Northwestern researchers said. Knowing which patients carry this genetic marker also will guide doctors in how they treat the cancer.

A nanocomposite particle can be constructed so that it has a mix of properties that would not otherwise happen in nature. By combining an organic matrix with metallic clusters that can absorb light, it is possible to incorporate such particles into cells and then destroy those targeted cells with a laser. In a presentation at the NSTI Nanotech 2007 Conference, researchers describe work regarding the creation and characterization of a dendrimer nanocomposite (DNC) matrix containing silver clusters that can be used to target and destroy melanoma cancer cells.