OTTAWA, January 21, 2011 /PRNewswire/ --

Highlights: - Resumed position as a key supplier in the molybdenum-99 (Mo-99) supply chain with the restart of the National Research Universal (NRU) reactor - Established long-term supplemental supply of Mo-99 with Russian supplier, Isotope - Ended fiscal 2010 in a solid liquidity position and with financial flexibility, announcing dividend and Normal Course Issuer Bid (NCIB) program in January 2011 - Initiated reporting on three segments: Medical Isotopes, Targeted Therapies, and Sterilization Technologies

- Nordion reports in U.S. dollars unless otherwise specified

Nordion Inc. , a leading provider of products and services to the global health science market, today reported its fourth quarter and fiscal 2010 financial results. The Company also filed its 2010 Annual Report, which includes audited consolidated financial statements and notes for the year ended October 31, 2010, and related management's discussion and analysis, the 2010 Annual Information Form, and the 2011 Management Proxy Circular.

Revenues from continuing operations of $85.8 million were up $34.4 million or 67% in the fourth quarter of fiscal 2010, compared with $51.4 million in the fourth quarter of fiscal 2009. Income from continuing operations was $9.3 million ($0.14 earnings per share), compared with a loss of $18.2 million ($0.14 loss per share) in the fourth quarter of fiscal 2009.

In fiscal 2010, revenues from continuing operations were $240.4 million, up 4% compared with fiscal 2009. The loss from continuing operations was $103.3 million ($1.16 loss per share), a significant increase from a loss of $11.7 million ($0.10 loss per share) in fiscal 2009.

"Nordion's financial results strengthened in the fourth quarter across all three business segments," said Mr. Steve West, Chief Executive Officer, Nordion Inc. "Increased sales in the Sterilization Technologies business, a resumption of activity in the Mo-99 supply chain, and improved performance of key Targeted Therapies products contributed to stronger revenues."

"Now that Nordion has completed the strategic repositioning, we're focused on driving improved profitability and cultivating sustainable growth," added Mr. West.

Key Q4 Events: - Nordion extended its existing agreement with Ontario Power Generation, Inc., securing supply of cobalt-60 (Co-60) for the Company until 2020. - The NRU reactor, Nordion's primary source of Mo-99 supply, returned to operation and Nordion resumed its role in the medical isotope supply chain. - Nordion announced that Kenneth Newport was appointed to the Board of Directors. - Nordion entered into a framework agreement with Russian Rosatom State Corporation's subsidiary, Open Joint Stock Company Isotope (Isotope), and signed an agreement for the exclusive supply of Mo-99 for processing, distribution and sale outside the Russian Federation until 2020. Subsequent to the quarter: - On November 1, 2010, the Company completed its name change from MDS Inc. to Nordion Inc. - On December 2, 2010, Nordion announced it had signed a non-binding letter of intent to divest its Belgian subsidiary, MDS Nordion S.A. - On December 23, 2010, Nordion announced that the first sample of Mo-99 had been shipped from Isotope. - On January 5, 2011, Nordion announced it had extended its Mo-99 supply contract with a major customer, Lantheus Medical Imaging, Inc., until December 31, 2013. - On January 20, 2011, Nordion announced the introduction of an annual dividend of $0.40 per share, to be payable on a quarterly basis, and an NCIB program.

"Nordion demonstrated resilience throughout 2010," said Peter Dans, Chief Financial Officer. "By focusing on operational and financial performance, the Company exited the year with the financial flexibility that allows us to return cash to shareholders through our announced dividend and NCIB."

Medical Isotope Update

The restart of the NRU reactor was a major event for Nordion in the fourth quarter of fiscal 2010. It supported the Company's return as a key player in the Mo-99 supply chain and as an important partner to its customers.

The current medical isotope landscape is significantly different when compared with the landscape Nordion operated in prior to the NRU reactor shutdown in May 2009. These changes created uncertainty in the medical isotope market, in general, and has specifically impacted Nordion. Several factors, as discussed in the 2010 Management Discussion and Analysis (MD&A) filed today, have affected key drivers of the Company's profitability of its Medical Isotopes segment, including pricing and demand for medical isotopes, and in particular, for Mo-99. As a result, based on activity since the NRU reactor restarted in late-August 2010, the Company currently expects revenue and segment earnings contribution for the first and second quarter of fiscal 2011 to be similar to our results for medical isotopes in the fourth quarter of fiscal 2010. This indicates that lower demand and reduced market share are expected to offset price increases compared with what it was prior to the May 2009 shutdown. Nordion continues to work with existing customers and is in discussions with potential new customers to increase its global market share of Mo-99.

The Company continues to expect to receive its first commercial shipment of supplemental Mo-99 product from its Russian partner, Isotope, in the first half of fiscal 2011. Supply is anticipated to be available to partially offset the impact of an approximately one-month long shutdown of the NRU reactor scheduled by Atomic Energy of Canada Limited (AECL) in mid-May of 2011. Nordion will not receive product from the NRU reactor for the majority of the shutdown period. While the anticipated Mo-99 supply from Isotope during the planned shutdown of the NRU reactor is expected to be substantially less than the Company currently receives from the NRU reactor, the agreement with Isotope establishes Nordion as a reliable supplier of Mo-99 over the mid- to long-term and strengthens its relationships with customers. Over several years, the expectation is to have supply available of up to 20% of global Mo-99 demand to back up long-term requirements.

MAPLE Arbitration Update

Hearings for the arbitration with AECL related to the MAPLE Facilities are proceeding, and the Company currently expects them to conclude in the fall of 2011, with a decision from the panel following the conclusion of the hearings.

Fourth Quarter and F2010 Results

Three months ended Twelve months ended October 31 October 31 2010 2009 2010 2009 Consolidated Results (thousands of U.S. dollars, except where noted) Consolidated Revenues from continuing operations $ 85,841 51,411 $ 240,352 231,263 Gross margin 53% 46% 47% 49% Operating income (loss) from continuing operations $ 15,394 (11,985) (106,405) (1,616) Income (loss) from continuing operations $ 9,280 $ (18,228) $ (103,348) $ (11,650) - Basic earnings (loss) per share from continuing operations $ 0.14 $ (0.14) $ (1.16) $ (0.10) Net income (loss) $ 15,672 $ (58,658) $ (232,010) $ (135,241) Cash and cash equivalents $ 122,802 $ 298,203 $ 122,802 $ 298,203 Share buyback - thousands of shares - - 52,941 - Weighted average number of Common shares outstanding - basic (thousands of shares) 67,237 120,137 89,279 120,137

Continuing Operations by Segment

- Consolidated revenues from continuing operations in the fourth quarter of fiscal 2010 were $85.8 million, up $34.4 million or 67%, compared with the fourth quarter of fiscal 2009. The increase was primarily due to higher revenues from Medical Isotopes as a result of the NRU reactor resuming operations in August 2010, higher Targeted Therapies revenues primarily due to increased shipments of TheraSphere(R) and CardioGen-82TM products, and higher Sterilization Technologies revenues as a result of increased shipments of Co-60 and the sale of a production irradiator. Gross margin was 53%, compared with 46% in the fourth quarter of the previous fiscal year.

- Income from continuing operations in the fourth quarter of fiscal 2010 was $9.3 million, up $27.5 million, compared with the fourth quarter of fiscal 2009. Other than a favourable $13 million change in the fair value of embedded derivatives primarily associated with the Company's Russian Mo-99 supply agreement, the increase was primarily due to improved segment earnings from Medical Isotopes and Sterilization Technologies. Additionally, the Company incurred lower restructuring costs in the fourth quarter of fiscal 2010 compared with in the same quarter in fiscal 2009.

- Other items impacting income from continuing operations in the fourth quarter of fiscal 2010 also included:

- Selling, general and administrative (SG&A) expenses of $29.3 million, up $8.4 million compared with the same period of fiscal 2009 primarily due to a $2.8 million increase in cost associated with the MAPLE arbitration, higher costs associated with transition activities, higher incentive and stock-based compensation, and an unfavorable operational foreign exchange impact.

- $2.5 million of restructuring costs primarily related to facilities, compared with $8.5 million of restructuring charges in the fourth quarter of fiscal 2009.

- Other expenses, net of $4.0 million, up $5.4 million compared with an income of $1.4 million the same period of fiscal 2009.

- Cash and cash equivalents of $122.8 million as of October 31, 2010, was $175.4 million lower compared with $298.2 million as of October 31, 2009, but up $1.5 million from the end of the third quarter of 2010. Factors impacting year over year cash balances are described in the liquidity section of the Company's 2010 MD&A filed today, and include the effects of divestures, share buybacks, debt settlement, and operational needs. In the fourth quarter of 2010, payments for restructuring costs and income taxes remittances were funded primarily from positive operational cash flow and the sale of an Asset-backed commercial paper investment.

Medical Isotopes

Three months ended Twelve months ended October 31 October 31 2010 2009 2010 2009 Consolidated Results (thousands of U.S. dollars, except where noted) Revenues $ 27,907 7,835 57,958 94,412 Segment earnings (loss) 7,987 (2,055) 4,146 31,813 Gross margin 49% 15% 37% 49%

Medical Isotopes revenues increased $20.1 million or 256% in the fourth quarter of fiscal 2010 compared with the same quarter in fiscal 2009 primarily due to the restart of the NRU reactor, which occurred in late-August. The impact of the NRU reactor-based isotopes was partially offset by a 7% decline in cyclotron isotopes as they returned to normal levels.

Revenues of $58.0 million for the entire fiscal 2010 decreased by $36.4 million or 39% compared with fiscal 2009 primarily due to the outage of the NRU reactor, resulting in a 55% decrease in reactor-based isotope revenues. The decrease in reactor-supplied revenues was partially offset by cyclotron product revenues, which were 22% higher in fiscal 2010 compared with fiscal 2009, mainly driven by demand for Thallium-201, which was used as a substitute for Mo-99 due to shortages resulting from the NRU reactor shutdown and disruption to supply from the High Flux Reactor in the Netherlands in fiscal 2010.

Targeted Therapies

Three months ended Twelve months ended October 31 October 31 2010 2009 2010 2009 Consolidated Results (thousands of U.S. dollars, except where noted) Revenues $ 19,851 14,660 65,552 42,261 Segment earnings (loss) 1,980 2,229 6,582 261 Gross margin 48% 42% 41% 38%

Targeted Therapies revenues increased $5.2 million or 35% in the fourth quarter of fiscal 2010 compared with the same quarter in fiscal 2009 reflecting strong performance by TheraSphere(R) and CardioGen-82(TM) products. Segment earnings decreased $0.3 million or 11% as increased research and development spending on TheraSphere(R) and the decommissioning of a production facility in Fleurus, Belgium offset the contribution from stronger product sales.

Revenues of $65.6 million in fiscal 2010 increased by $23.3 million or 55% compared with fiscal 2009. The increase was due to the continued strong performance of a number of products, primarily CardioGen-82(TM) along with the global performance of TheraSphere(R) which grew by 40% in 2010.

Sterilization Technologies

Three months ended Twelve months ended October 31 October 31 2010 2009 2010 2009 Consolidated Results (thousands of U.S. dollars, except where noted) Revenues $ 38,083 28,916 116,842 94,590 Segment earnings (loss) 17,706 13,203 46,861 35,085 Gross margin 60% 57% 54% 53%

Sterilization Technologies revenues increased $9.2 million or 32% in the fourth quarter of fiscal 2010 compared with the same quarter in fiscal 2009 as a result of increased shipments of Co-60 and the sale of one production irradiator. As a result of higher revenue, segment earnings increased by $4.5 million or 34%.

Revenues of $116.8 million in fiscal 2010 increased $22.2 million or 24% compared with fiscal 2009. The increase was primarily due to increased volume and pricing of Co-60 and the shipment of two production irradiators in fiscal 2010, compared with one in fiscal 2009.

Corporate and Other

Corporate and Other recorded a loss of $9.5 million in the fourth quarter of fiscal 2010, up $1.7 million or 22% compared with a loss of $7.8 million in the fourth quarter of fiscal 2009. The increase in the operating loss was primarily due to higher costs associated with transition activities, higher annual incentive costs, mark-to-market valuation of deferred share units, and unfavourable operational foreign exchange impact.

A segment loss of $66.1 million for Corporate and Other was recorded in fiscal 2010, up $25.2 million or 62% compared with fiscal 2009. The increase in the operating loss was mainly due to higher SG&A costs associated with transition and strategic repositioning activities, and a non-cash foreign exchange loss of approximately $27 million primarily resulting from the revaluation of $450.0 million of proceeds from the sale of MDS Analytical Technologies that were held in a Canadian dollar functional currency entity in U.S. dollars to fund the substantial issuer bid.

Discontinued Operations

Nordion recorded an operating loss of $3.2 million in the fourth quarter of fiscal 2010, compared with an operating loss of $7.3 million in the fourth quarter of fiscal 2009. The decrease was primarily due to completion of the strategic repositioning in fiscal 2010.

An operating loss of $62.0 million was recorded in fiscal 2010, compared with a loss of $91.3 million in fiscal 2009. The operating loss in fiscal 2010 was primarily a result of the MDS Pharma Services Early Stage business whereas the operating loss in fiscal 2009 included the operating performance of MDS Pharma Services Early Stage and Late Stage businesses, as well as MDS Analytical Technologies.

Conference Call

Nordion will hold a conference call on Friday, January 21, 2011 at 9:30 am ET to discuss its fourth quarter and fiscal 2010 results. This call will be webcast live at http://www.nordion.com, and will be available after the call in archived format at http://www.nordion.com/investors/webcasts_and_presentations.asp. To participate, please dial +1-866-223-7781 (toll-free North America) or +1-416-340-8018 (International).

Nordion's 2010 Annual Report and Annual Information Form, and the 2011 Management Proxy Circular can be accessed on the Company's website at http://www.nordion.com/investors/annual_reports.asp.