Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer.

The discovery of CDK8's role in cancer was made possible by new tools for assessing the activity of specific genes, say the authors of the new study. As these tools are further improved, the stream of newly discovered cancer genes is expected to increase, providing new avenues for therapy, the authors suggest in Nature on Sept. 14.

The study is noteworthy in another respect, as well, the authors indicated. Many of the abnormal proteins linked to cancer are known as "transcription factors" because they're able to "read" cell DNA and use that information for producing other cell proteins. Although transcription factors are important regulators, this class of proteins has proven to be impossible to target with drugs. Genes that influence such transcription factors, however, make attractive targets for drugs, since they can potentially disrupt the cancer process and disable tumor cells. CDK8 is such a gene.

What happened to my jugs? They’re huge! I’m talking about my milk jugs, of course. No, seriously -- those large, plastic, gallon-sized jugs that you buy at the store that are filled with milk. It seems that they’ve gone through quite a growth spurt all of the sudden.

Milk Jugs - The New and the Old

Why the sudden design change? Transitioning to the new “squared off” jugs saves money, materials, time, and fuel… all things that are good for businesses, consumers, and the environment. The new-fangled jugs started showing up in selected Costco, WalMart, and Sam’s Club stores last fall. But because of the savings they represent, they are certain to start appearing in grocery stores all around the country before long.

The crashing of the enormous fluked tail on the surface of the ocean is a “calling card” of modern whales.

Living whales have no back legs and use their front legs as 'flippers' that allow them to steer. Their tails provide the powerful thrust necessary to move their huge bulk.

Yet this has not always been the case, according to research in the latest issue of the Journal of Vertebrate Paleontology. Paleontologist Mark D. Uhen of the Alabama Museum of Natural History describes new fossils from Alabama and Mississippi that pinpoint where tail flukes developed in the evolution of whales.

Almost every bad thing a teenager does gets attributed to the 'crowd' they hang out with - few parents confess to having the troublemaker kid. Now an RTI International researcher says that goes for weight gain in kids too.

It isn't your fault for letting them eat junk food; it's their friends, for also being overweight.

The study, published in the September issue of Journal of Health Economics says that friends' weight is correlated with an adolescent’s own weight even after considering demographics, smoking status, birth weight, and household characteristics such as parental obesity.

Fort Miami wasn't a fort at all, according to discoveries made this summer by members of the University of Cincinnati's Ohio Valley Archaeology Field School project, who spent weeks working at the site in Hamilton County's Shawnee Lookout park.

What they found actually offers great insight into the cultural priorities of the Shawnee – the human labor that went into building the earthworks were done for agricultural purposes, not military. The earthworks were not a fort, but a water management system of dams and canals built to counter the impact of long-term drought.

It is also much larger than previously believed – so large, in fact, that its berms stretch to almost six kilometers in length, making it twice as large as any other Native American earthworks in Ohio, and one of the largest in the nation.

Fort Miami.

The phenomenon of "shimmering" in giant honeybees, in which hundreds or even thousands of individual honeybees flip their abdomens upwards within a split-second to produce a Mexican Wave-like ("Mexican Wave" is British English for what Americans just call "the wave" - when fans in sections of the stadium stand up in sequence to cheer) pattern across the bee nest, has received much interest but both its precise mode of action and its purpose have long remained a mystery.

In a new study published this week, researchers at the University of Graz, Austria, and the Royal Botanic Gardens Kew, UK, report the finding that shimmering—a remarkable capacity of rapid communication in giant honeybees—acts as a defensive mechanism, which repels predatory hornets, forcing them to hunt free-flying bees, further afield, rather than foraging bees directly from the honeybee nest.


titlePlain: The time courses of shimmering of Giant honeybees in response to approaching hornets. The waving strength W ( = number of abdomen-shaking bees per frame) depends on the hornets distances from the nest dxz (A) and on the hornets\' flight velocities vxz (B); time zero defines the onset of the waves; (A) five dxz classes (Cdxz = 1–5; coded in yellow to red; for definition, see Methods and Fig. 4,5) and (B) eight vxz classes (Cvxz = 1–8; coded in green to blue) of hornet flight episodes were considered; dxz and vxz class values were assessed from hornets in the 400 ms interval prior to the start of shimmering. Curves show arithmetical means, thin vertical lines denote SEM. For data details, see table 1 and 2.

Endeavour International Corporation today announced a discovery at the site of its Noatun C prospect located in PL107 in the Norwegian North Sea. The well encountered a gas condensate column in the targeted Middle to Lower Jurassic sandstone. The drilling of a sidetrack will begin immediately to locate the gas water contact and further determine the size of the discovery.

The Noatun C was drilled to a total depth of 5,110 meters (16,765 feet) below sea level in approximately 293 meters (958 feet) of water. Logging and formation tests confirm the presence of gas condensate. The prospect is one of several satellites to be drilled by Endeavour and the operator StatoilHydro as potential tie backs to the Njord field that lies 16 kilometers south of the discovery. Two well bores, a discovery well and an appraisal well, drilled during the second quarter of 2008 at the Galtvort prospect in PL348 also encountered gas condensate. These successes followed a gas condensate discovery in late 2007 at the Njord Northwest Flank prospect west of the Njord field in PL107. Endeavour holds a 2.5 percent equity interest in the Noatun, Galtvort, and the Njord Northwest Flank discoveries and the Njord field.

Brage Satellites

Children who wear glasses are being bullied at school, to the extent that some play truant to avoid playground taunts - and it's because of the glasses, not because some kids are just not cool, says Specsavers.

Research commissioned by them to mark the inaugural National Glasses Day on Friday September 19th reveals that a quarter of children were sad when they were told that they had to wear specs.

Being told 'Johnny Depp wears glasses' did not seem to help so Specsavers has commissioned iconic specs wearer Gok Wan, presenter of C4's "How to Look Good Naked", and anti-bullying charity Kidscape to encourage all specs wearers to wear their glasses with pride and draw attention to bullies who ridicule people because of how they look.

All 3,000 Virgin Trains staff (that get seen by customers) will be sporting a new look today following the delivery of new uniforms.

The difference? All of the Wensum-supplied garments are 'eco-friendly.'

What does that mean? Leave it to Richard Branson to make clothes that can be thrown in a washing machine an ecological PR move. Both the garments and the package are also recycleable, they say, and the manufacturer treats its workforce within full Human Rights conditions, though that would seem to be a bonus outside the environment.

To build a hospital, nuclear power station or a large dam you need to know the possible earthquake risks of the terrain. Now, researchers from the Universities of Granada and Jaen, alongside scientists from the University of California (Santa Barbara, USA), have developed, based on relief data from the southern edge of the Sierra Nevada, a geomorphological index that analyses land form in relation to active tectonics, applicable to any mountain chain on the planet.

Active tectonics comprise the most up-to-date deformation processes that affect the Earth's crust, resulting in earthquakes or recent deformations in the planet’s faults and folds. This phenomena is analysed in geology research carried out before commencing engineering works.