Abnormally high levels of P-cadherin – an adhesion molecule that enables cells to bind together – occur in about a third of all breast cancers and are associated with poor prognosis. Portuguese researchers , writing in the journal Oncogene1, found that the reason why these cancers are more aggressive is because excessive P-cadherin changes the cancer cells’ internal organization, making them mobile and invasive (invasiveness is the capacity to cross biological barriers such as membranes). Both these characteristics allow the formation of metastases - which is the spread of cancer cells from the original site of the tumour to other parts of the body - increasing the disease aggressiveness and explaining the poor prognoses associated with P-cadherin.

Although the H1N1 vaccine is generally believed to be safe and effective, researchers from the University of Missouri have uncovered evidence that taking over-the-counter pain relievers, like aspirin and Tylenol, can reduce the effectiveness of the vaccine because they inhibit the normal function of enzymes that help regulate the immune system.

 The role of these enzymes, called COX enzymes, is not yet understood completely, and
medications that inhibit them may have adverse side effects. Recent research has discovered that drugs that inhibit COX enzymes, such as COX-2, have an impact on the effectiveness of vaccines. This new research indicates that inhibiting COX-1, which is present in tissues