Researchers at the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) have identified a potential new drug target for the treatment of Parkinson’s disease and possibly for other degenerative neurological disorders.

The investigators have found, in cellular and animal models, that blocking the action of an enzyme called SIRT2 can protect the neurons damaged in Parkinson’s disease from the toxic effects of alpha-synuclein, a protein that accumulates in the brains of Parkinson’s patients. The study also suggests that inhibiting this pathway could help in the treatment of other conditions in which abnormal proteins accumulate in the brain.

In a new, large-scale, prospective study exploring the link between levels of urate in the blood and risk of Parkinson’s disease, researchers from the Harvard School of Public Health (HSPH) have found that high levels of urate are strongly associated with a reduced risk of the disease. The findings were published online on June 20, 2007 in The American Journal of Epidemiology and will appear in an upcoming print issue of the journal.

Urate is a normal component of blood, and although high levels can lead to gout, urate might also have beneficial effects because it is a potent antioxidant.

What has the ENOCODE project done, and how do their results change our understanding of the human genome? In Time to Rethink the Gene? I put this project into perspective by briefly outlining some past concepts of the gene and highlighting some of the ENCODE findings. Now it's time to take a closer look at the results of the ENCODE project and their significance for our understanding of the human genome. ENCODE's genome snapshot is unquestionably fascinating, and it suggests that some features of genome regulation that were previously viewed as exceptions to the norm are really quite common. But are these results revolutionary?

"Nothing there," is what Case Western Reserve University physicists concluded about black holes after spending a year working on complex formulas to calculate the formation of new black holes. In nearly 13 printed pages with a host of calculations, the research may solve the information loss paradox that has perplexed physicists for the past 40 years.

"It's complicated and very complex," noted Case physicists Tanmay Vachaspati, Dejan Stojkovic and Lawrence M. Krauss, regarding both the general problem and their particular approach to try to solve it.

The question that the physicists set out to solve is: what happens once something collapses into a black hole" If all information about the collapsing matter is lost, it defies the laws of quantum physics.

An international team including researcher Ermanno Borra, from Université Laval’s Center for Optics, Photonics, and Laser, have found a combination of materials that allows the creation of a highly reflective liquid mirror capable of functioning even on the moon's harsh landscape.

Science fiction? Not at all.

Liquid mirror telescopes differ from conventional telescopes by their primary mirrors—the ones that gather and focus light—which are made from a reflective liquid instead of polished glass. Poured into a spinning container, the liquid spreads out and forms a thin, perfectly smooth, and parabolic shape that can be used as a telescope mirror.

3.7-m diameter liquid mirror at Laval University.

Plants absorb carbon dioxide from the air and combine it with water molecules and sunshine to make carbohydrate or sugar. Variations on this process provide fuel for all of life on Earth.

University of Wisconsin-Madison chemical and biological engineering Professor James Dumesic and his research team describe a two-stage process for turning biomass-derived sugar into 2,5-dimethylfuran (DMF), a liquid transportation fuel with 40 percent greater energy density than ethanol.

The prospects of diminishing oil reserves and the threat of global warming caused by releasing otherwise trapped carbon into the atmosphere have researchers searching for a sustainable, carbon-neutral fuel to reduce global reliance on fossil fuels.

Sediment cores retrieved from the Arctic’s deep-sea floor by the Integrated Ocean Drilling Program’s Arctic Coring Expedition (ACEX) report that the Arctic Ocean changed from a landlocked body of water (a ‘lake stage’) through a poorly oxygenated ‘estuarine sea’ phase to a fully oxygenated ocean at 17.5 million years ago during the latter part of the early Miocene era.

The authors attribute the change in Arctic conditions to the evolution of the Fram Strait into a wider, deeper passageway that allowed an inflow of saline North Atlantic water into the Arctic Ocean.

Scientists have long thought that microtubules, part of the microscopic scaffolding that the cell uses to move things around in order to hold its shape and divide, originated from a tiny structure near the nucleus, called the centrosome.

Now, researchers at Vanderbilt University Medical Center reveal a surprising new origin for these cellular "highways." Irina Kaverina, Ph.D., and colleagues report that the Golgi apparatus -- a stack of pancake-shaped compartments that sorts and ships proteins out to their cellular destinations -- is the source of a particular subset of these microscopic fibers. The findings point to a novel cellular mechanism that may guide cell movement and possibly cancer cell invasion.

Women cheat on men for their own needs but superb starling females stray from their mates for the sake of their chicks, according to recent Cornell research. This reasoning includes being able to know if mates are too 'genetically similar' for breeding.

That gives 'doing it for the kids' a whole new layer of meaning. The study found that superb starling females (Lamprotornis superbus) cheat on their mates based on these factors:

• Superb starlings are cooperative breeders, meaning breeding pairs get help in raising chicks from other family group members. Some females mate with subordinate males when they need help to raise their chicks.