The genome of the organism that produces the world's most lethal toxin is revealed today. This toxin is the one real weapon in the genome of Clostridium botulinum and less than 2 kg - the weight of two bags of sugar - is enough to kill every person on the planet. Very small amounts of the same toxin are used in medical treatments, one of which is known as Botox®.

The genome sequence, reported in Genome Research, shows that C. botulinum doesn't have subtle tools to evade our human defences or tricky methods of acquiring resistance to antibiotics. It lives either as a dormant spore or as a scavenger of decaying animal materials in the soil, and doesn't interact with human or other large animal hosts for prolonged periods of time.

Next time there is a global pandemic, contaminated water caused by flooding, or questionable-looking meat in a supermarket, we may be reaching for a piece of paper.

It won’t be just any type of paper but a Canadian-invented bioactive paper that contains the ingredients to detect and ward off life-threatening bacteria and viruses like E-coli, salmonella and SARS, to name just a few.

Two genes important for human development and implicated in cancer and schizophrenia also help keep a healthy balance between excitation and inhibition of brain cells, researchers say.

Neuregulin-1 and its receptor, ErbB4, promote inhibition at the site of inhibitory synapses in the brain by increasing release of GABA, a major inhibitory neurotransmitter, Medical College of Georgia researchers led by Dr. Lin Mei report in the May 24 issue of Neuron.

Fragile X syndrome is the most common form of inherited mental retardation, occurring in 1 in 3600 males and 1 in 4000 to 6000 females.

To understand the details of the neuronal pathology of Fragile X syndrome, the researchers studied mice in which the same gene that causes the disease in humans had been knocked out. The scientists performed a detailed analysis of the electrophysiological properties of neurons in the prefrontal cortex, a region responsible for higher cognitive functions, including learning and memory, that are affected in humans with the disorder.

McDonald's new advertising campaign to promote high-level career opportunities within the company is a great way to fight the connotation of dead-end drudgery and low wages that comes with "McJobs," according to Jerry M. Newman, SUNY Distinguished Teaching Professor in the University at Buffalo School of Management.

Having worked undercover at seven fast-food restaurants across the United States, including McDonald's, Burger King and Wendy's, Newman, author of "My Secret Life on the McJob," says that McDonald's has the right idea in its newest television commercial.

The spot features Karen King, president of McDonald's USA East Division, extolling the virtues of the high schooler who gets a job at McDonald's, working hard and taking advantage of opportunities.

Shire plc today announced that VYVANSE™ (lisdexamfetamine dimesylate) effectively controlled Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children aged 6 to 12 years. In addition, 95 percent of children taking VYVANSE daily for 12 months showed overall improvement, according to phase III open-label extension trial results. Further analysis of phase II clinical data demonstrated that VYVANSE provided consistent time to maximum concentration of d-amphetamine from patient to patient. Both studies were presented today at the annual meeting of the American Psychiatric Association (APA).

Thymic nurse cells were given their name because of their intimate relationship with developing T cells (thymocytes) in the thymus.

Thymic nurse cells have been reported to take as many as 50 thymocytes into their cell body (see thymocytes inside of a thymic nurse cell in photos, the blue dye stains the nuclei of thymocytes inside of a nurse cell). Whether or not thymic nurse cells have the capacity to "internalize" another cell into itself, and the function of this unique biological phenomenon during T cell development is the focus of studies performed by Dr. Guyden at The City College of New York and his colleagues at Tuskegee University.

Regulatory oversight of nanotechnology is urgently needed and the Environmental Protection Agency (EPA) should act now, reports a new study released today. In EPA and Nanotechnology: Oversight for the 21st Century, former EPA assistant administrator for policy, planning and evaluation, J. Clarence (Terry) Davies, provides a roadmap for a new EPA to better handle the challenges of nanotechnology. New nanomaterials and nanotechnology products are entering the market each week, and an adequate oversight system is necessary to identify and minimize any adverse effects of nano materials and products on health or the environment.

The hydrogen economy is not a futuristic concept. The U.S. Department of Energy's 2006 Advance Energy Initiative calls for competitive ethanol from plant sources by 2012 and a good selection of hydrogen-powered fuel cell vehicles by 2020.

Researchers at Virginia Tech, Oak Ridge National Laboratory (ORNL), and the University of Georgia propose using polysaccharides, or sugary carbohydrates, from biomass to directly produce low-cost hydrogen for the new hydrogen economy.

Nature, through the trial and error of evolution, has discovered a vast diversity of life from what can only presumed to have been a primordial pool of building blocks.

Inspired by this success, a new Biodesign Institute research team, led by John Chaput, is now trying to mimic the process of Darwinian evolution in the laboratory by evolving new proteins from scratch. Using new tricks of molecular biology, Chaput and co-workers have evolved several new proteins in a fraction of the 3 billion years it took nature.