Women in rural India spend hours together traversing vast tracts of hilly terrain to collect the firewood for household leaving their family and children at home. Some times there is "Pakad" i.e. Forest Officials detain them and fine them Rs 2100 as they nerrated. Besides facing the hazards to wild life and human beings praying on lonely women in woods they face the smoke and closed door cooking in dingy houses without the smoke outlet their kids are also exposed to high dosages of smoke.

Physicians have long recognized that pinpointing specific causes of disease in individual patients enables therapies that are the most likely to confer benefit with the fewest adverse effects. We also recognize the potential for disease prevention through identification of specific risk factors and mitigation of their effects. For a century, we have known that many of these risk factors are genetic. In the past 20 years, the genomic revolution has translated this knowledge into a new understanding of disease: mutations that cause more than 2000 mendelian diseases have been identified, which has led to the rewriting of textbooks of pathophysiology of every organ system and the identification of rational targets for therapeutic intervention.