A 115-year-old woman who had remained mentally alert throughout her life had no evidence of Alzheimer's disease, according to a study in the August issue of Neurobiology of Aging, questioning the assumption that Alzheimer's disease or other forms of dementia will inevitably develop, if people live long enough.
Prof. dr. Gert Holstege of University Medical Centre Groningen, The Netherlands and colleagues had a unique chance to test the mental functioning of one of the world's oldest humans, and then to compare their findings with the condition of the subject's brain after death.
The patient was a Dutch woman who, at age 82, made arrangements to donate her body to science after death. At age 111, she contacted the researchers to ask whether her body would still be useful for research or teaching purposes. They assured her that, contrary to what she thought, they were especially interested because of her age: "She was very enthusiastic about her being important for science," Dr. Gert Holstege and colleagues write.