There is no clear benefit from a hormone commonly prescribed to enhance the effectiveness of infertility treatments, according to a new review of studies.

The steroid hormones called glucocorticoids have potent effects on the body’s inflammatory and immune responses, so many fertility specialists prescribe them in hopes of making the lining of the uterus more receptive to embryo implantation. But lead review author Carolien Boomsma says that routine practice should stop.

“This meta-analysis shows that empirical use of glucocorticoids is not supported by evidence from studies,” she said. “Moreover, we don’t know enough about the possible adverse effects of glucocorticoids in early pregnancy.

New research has examined the usefulness of bone marrow stem cells for treating male infertility, with promising results. The related report by Lue et al, “Fate of bone marrow stem cells transplanted into the testis: potential implication for men with testicular failure,” appears in the March issue of The American Journal of Pathology.

When a couple experiences infertility, the man is just as likely as the woman to be the cause. Male infertility may arise from failed proliferation and differentiation of the germ cells (precursors of sperm) or from dysfunction of the supporting cells. New research is looking to stem cells as a means of replacing nonfunctioning cells, whether germ cells or supporting cells.

Researchers, directed by Dr. Ronald S.

A wedge of sediment, pushed up by glacial movement, may be a buffer against moderate sea level rise, pointing to ocean temperature rise as the key factor in glacial retreat, according to two papers published today (March 1) in Science Express.

"Sediment beneath ice shelves helps stabilize ice sheets against retreat in response to rise in relative sea level of at least several meters," says Richard Alley, the Evan Pugh professor of geosciences, Penn State.

In the March 2007 issue of BioScience, an international team of 19 researchers calls for better forecasting of the effects of global warming on extinction rates. The researchers, led by Daniel B. Botkin, note that although current mathematical models indicate that many species could be at risk from global warming, surprisingly few species became extinct during the past 2.5 million years, a period encompassing several ice ages. They suggest that this "Quaternary conundrum" arises because the models fail to take adequate account of the mechanisms by which species persist in adverse conditions.

Researchers at Yale have identified multiple pathogenic "alien islands" in the genome of the A. baumannii, bacteria that has been responsible for new and highly drug-resistant infections in combat troops in the Middle East, according to a report in the March 1 issue of Genes and Development.

"Drug resistant bacterial infections are a rapidly growing problem in hospital settings, and now in difficult conditions of combat. We targeted A. baumannii as a growing threat for our troops in Iraq," said s principal investigator Michael Snyder, the Lewis B Cullman Professor of Molecular Cellular & Developmental Biology.

Researchers have used the world's thinnest material to create the world's smallest transistor – a breakthrough that could spark the development of a new type of super-fast computer chip.

Professor Andre Geim and Dr Kostya Novoselov from The School of Physics and Astronomy at The University of Manchester, reveal details of transistors that are only one atom thick and less than 50 atoms wide, in the March issue of Nature Materials.

They believe this innovation will allow the rapid miniaturisation of electronics to continue when the current silicon-based technology runs out of steam.

In recent decades, manufacturers have crammed more and more components onto integrated circuits.

Scientists of the US CMS collaboration joined colleagues around the world in announcing today (February 28) that the heaviest piece of the Compact Muon Solenoid particle detector has begun the momentous journey into its experimental cavern 100 meters underground. A huge gantry crane is slowly lowering the CMS detector's preassembled central section into place in the Large Hadron Collider accelerator at CERN in Geneva, Switzerland. At 1,950 metric tons, the section, which contains the detector's solenoid magnet, weighs as much as five jumbo jets and is 16 meters tall, 17 meters wide and 13 meters long.

In this equation, it's probably pretty obvious what you should do. But is your life ruled by should? Do you gimp through your week yessir-ing and nomam-ing and cowtowing to avoid punishment? Okay, so do most of us—but here's your chance to break the mold and stike a blow for the proletariat (viva la revolucion...). And at least if you get caught blowing off the rest of the day in favor of a four-hour, three-martini, expense account lunch at the pub, you can blame the numbers.

Should I order a sandwich at my desk or head to the bar on the corner for a blowout lunch?

The function of an enzyme in the brain – strongly linked to a number of major brain diseases such as Alzheimer's, schizophrenia and bi-polar disorder – has been identified for the first time by researchers at the University of Bristol, UK.

These findings, published today in Neuron, will help in the understanding of how memories are laid down and what goes wrong in these disorders.

The research showed how controlling the activity of glycogen synthase kinase-3 (GSK3) might prevent a memory being erased by improving the strength of connections between neurons in the brain, thus allowing better consolidation of new information.

Professor Collingridge from the University of Bristol said: "While GSK3 has previously been implicated in major neurological disorders, until now its rol