Using a special profiling technique, scientists at Princeton have determined the mechanism of action of a potent antibiotic, known as tropodithietic acid (TDA), leading them to uncover its hidden ability as a potential anticancer agent.

TDA is produced by marine bacteria belonging to the roseobacter family, which exist in a unique symbiosis with microscopic algae. The algae provide food for the bacteria, and the bacteria provide protection from the many pathogens of the open ocean.

DURHAM, N.C. -- Chronic inflammation in the gut increases the risk of colon cancer by as much as 500 percent, and now Duke University researchers think they know why.

Their new study points to a biomarker in the cellular machinery that could not only serve as an early warning of colon cancer, but potentially be harnessed to counteract advanced forms of the disease, the second-largest cause of cancer death in the U.S.

In the study, published online on February 4 in the journal Cell Stem Cell, Duke biomedical engineers show how colon cancer development is intricately linked to a specific microRNA that dictates how cells divide.

Immunotherapy is one of the hottest emerging areas of cancer research. After all, using the body's own cells to fight cancer can be more effective and less invasive than flooding the entire system with toxic chemicals.

Yubin Zhou, Ph.D., assistant professor at the Center for Translational Cancer Research at the Texas A&M Health Science Center Institute of Biosciences & Technology, is studying how to use light to control the immune system and induce it to fight cancer.

The battery life of implantable heart monitors must be improved to reduce the need for replacement and the risks this carries for patients, argue two senior doctors in The BMJ today.

Cardiologists John Dean and Neil Sulke say over half of patients with pacemakers will need new batteries and many need several replacements.

Not only is money wasted replacing batteries before they've expired, this "exposes patients to risk of serious complications, including life threatening infection," they warn.

FRANKFURT. In contrast to animals, plants form new organs throughout their entire life, i.e. roots, branches, flowers and fruits. Researchers in Frankfurt wanted to know to what extent plants follow a pre-determined plan in the course of this process. In the renowned journal "Current Biology", they describe the growth of secondary roots of thale cress (Arabidopsis thaliana). They have observed it cell by cell in a high-tech optical microscope and analysed it with computer simulations. Their conclusion: root shape is determined by a combination of genetic predisposition and the self-organization of cells.

When we look at the night sky, we see stars as tiny points of light eking out a solitary existence at immense distances from Earth. But appearances are deceptive. More than half the stars we know of have a companion, a second nearby star that can have a major impact on their primary companions. The interplay within these so-called binary star systems is particularly intensive when the two stars involved are going through a phase in which they are surrounded by a common envelope consisting of hydrogen and helium. Compared to the overall time taken by stars to evolve, this phase is extremely short, so astronomers have great difficulty observing and hence understanding it. This is where theoretical models with highly compute-intensive simulations come in.