Preclinical findings suggest that targeting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) can restore ferroptosis-driven cell death, pointing to new therapeutic strategies that may be used to induce ferroptosis and inhibit tumor growth.

Ferroptosis is a form of controlled cell death triggered by the toxic accumulation of lipid peroxides in the cell. Because lipid peroxides are generated through normal metabolic activities, cells also have mechanisms in place to defend against ferroptosis. Glutathione peroxidase 4 (GPX4) is one of the key defense mechanisms identified to date. 

A new paper finds that greenhouse gas emissions from standing dead trees in coastal wetland forests are not properly accounted for when assessing the environmental impact of so-called "ghost forests."

Ghost forests are what is left of former forests in coastal regions where changes led to shifts in the height of land. As salt water moves in, dead, white, trees are created. North Carolina has some that can even be seen from space.

If a post is not popular, you will never see it, so views count, but it is the message and not the popularity of it that persuades people, according to a new paper.

819 demographically diverse American adults aged 18-35 were shown two YouTube videos either for or against vaping. The pro-vaping videos were commercials for e-cigarette brands. The anti-vaping videos were public service announcements produced by anti-tobacco groups. What was changed was the view numbers that participants saw for the videos.

Participants saw view numbers either around 10, 100, 100,000 or 1,000,000.

The remains of 36 bubonic plague victims from a 16th century mass grave in Germany provide evidence that evolutionary adaptive processes, driven by the disease, may have conferred immunity on later generations of people from the region.

The researchers collected DNA samples from the inner ear bones of individuals in a mass grave in the southern German city of Ellwangen which experienced bubonic plague outbreaks in the 16th and 17th centuries. Then they took DNA samples from 50 current residents of the town. They compared their frequency spectra - the distribution of gene variants in a given sample - for a large panel of immunity-related genes and found that innate immune markers increased in frequency in modern people from the town compared to plague victims.

Men may be more reluctant to go to a doctor for chest pain but when they get to a care facility, a new analysis finds they get it quicker than women.

In this look at the data, all of the patients were younger, from 18-55. 

Compared with men, women were triaged less urgently, waited longer to be seen, and were less likely to undergo basic tests or be hospitalized or admitted for observation to diagnose a heart attack, according to a demographic look presented at the American College of Cardiology meeting. 

A new analysis finds that nearly 50 percent of people who have children with a partner who suffers from schizophrenia or bipolar disorder themselves meet the criteria for a mental disorder.