But those were living donors, and that is going to be rare because uterus donation is only available for women with friends or family members who will donate.
Yet lots of people donate organs after they die, so using transplants from deceased people became the next goal. And it has happened. A case study from Brazil published in The Lancet is the first successful live birth from a harvested uterus, after attempts with 10 other uterus transplants from deceased donors.
The time line:
September 2016. A 45 year-old mother died from a stroke involving bleeding on the surface of the brain and her uterus was removed. The recipient was a 32 year-old born without a uterus as due to Mayer-Rokitansky-Küster-Hauser syndrome, which affects about 1 in 4,500 women.
The recipient received five immunosuppression drugs, as well as antimicrobials, anti-blood clotting treatment and aspirin while in hospital. Immunosuppressive drugs continued.
By February of 2017, the uterus showed no signs of rejection and she was having regular menstruation.
Using eight fertilized eggs cryopreserved from in vitro fertilization four months before the transplant, the implantation occurred in April of 2017.
On December 15th, 2017, the baby was born via Caesarean, normal weight for gestational week 36. The uterus was removed during the same procedure and immunosuppressive therapy, which had continued throughout pregnancy, was halted.
Three days later they were discharged and when The Lancet article was written, the baby was seven months of age and breastfeeding normally.
This is a real breakthrough. It's the first of its kind, so complications may occur in the next one, but this could be a benefit for hundreds of thousands of women just in the United States.
Citation: Dani Ejzenberg, Wellington Andraus, Luana Regina Baratelli Carelli Mendes, Liliana Ducatti, Alice Song, Ryan Tanigawa, Vinicius Rocha-Santos, Rubens Macedo Arantes, José Maria Soares Jr, Paulo Cesar Serafini, Luciana Bertocco de Paiva Haddad, Rossana Pulcinelli Francisco, Luiz Augusto Carneiro D'Albuquerque, Edmund Chada Baracat, 'Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility', The Lancet, December 04, 2018 DOI:https://doi.org/10.1016/S0140-6736(18)31766-5
- Uterus Transplant Leads To First Successful Baby Delivery
- First Ovarian Transplant Between Non-identical Sisters
- Kidney Transplants From Extended Criteria Non-Beating Heart Donors Double Risk Of Death In Elderly
- Characteristics Of Transplant Patients Likely To Have A Potential Living Liver Donor
- Mild Hypothermia In Deceased Donors Improves Function After Kidney Transplant