In the fall of 2012, the European Medicines Agency approved the modified adeno-associated virus AAV-LPL S447X as the first ever gene therapy for clinical use in the Western world.

AAV-LPL S447X was developed for the treatment of a rare inherited metabolic disease called lipoprotein lipase deficiency which affects approximately 1-2 out of 1,000,000 people. Though incredibly rare, the disease causes severe, life-threatening inflammations of the pancreas. Afflicted individuals carry a defect in the gene coding for the lipoprotein lipase enzyme which is necessary for breakdown of fatty acids. AAV-LPLS447X shall be used as a viral vector to deliver an intact gene copy to affected cells.

In August of 2011, astronomers witnessed the dazzling appearance of the closest and brightest Type Ia supernova since Type Ia's were established as the "standard candles" for measuring the expansion of the universe.

The visual of SN 2011fe was caught by the Palomar Transient Factory less than 12 hours after it exploded in the Pinwheel Galaxy in the Big Dipper. Because it was to see through binoculars, 2011fe was soon dubbed the Backyard Supernova. Major astronomical studies from the ground and from space followed close on its heels, recording its luminosity and colors as it rapidly brightened and then slowly faded away. 

Since February 2013, China experienced an outbreak of the novel H7N9 avian flu, causing 131 cases of infection, and a death toll of 39. This particular H7N9 strain is considered to be one of the most worrisome pathogens since the H5N1 pandemic in 1997; a reputation based on the virus’ ability to spread easily across species and to infect humans. According to the May 23, 2013 Science paper published by the Joint Influenza Research Centre (State Key Laboratory of Emerging Infectious Diseases, Shantou PR, China), Drs. Y. Guan and Y. Shu reported that H7N9 infects the upper respiratory tract of ferrets and pigs, and spreads via direct contact, suggesting that the rapid surge of H7N9 infections are likely caused by human’s direct contact with infected birds.

For the past the 1,000,000 years the global climate has cycled every 100,000 years, between long glacial periods (with great masses of ice covering the continents in the northern hemisphere) and shorter interglacial periods, lasting around 10,000 years. It has been 12,000 years since the last one so enjoy that while it lasts.

However, within the long periods there have been abrupt climate changes, sometimes happening in the space of just a few decades, with variations of up to 10º C in the average temperature in the polar regions caused by changes in the Atlantic ocean circulation. These changes affected rainfall in southern Africa. 

While too much of anything can be bad at any time, a little drinking - 3 to 7 glasses of alcohol a week - does not seem to harm fetal neurodevelopment, according a large study published in the online only journal BMJ Open.

Good thing too, or entire generations of children would be mentally stunted - not drinking at all during pregnancy became the cultural norm a generation ago and it used the same kinds of longitudinal study that now says moderate drinking is okay.

And more affluent and better educated mums-to-be tend to drink more than women who are less well off, say the researchers, which means that kids from wealthier families should be neurodevelopmentally limited, but are not.

Goals need to be flexible, according to a new paper.  People who set a goal of losing between 2 and 4 pounds will still lose an average of 3 lbs. while a person who targets 3 lbs. specifically has less chance of success. 

Consumers often have a choice about the types of goals they want to set for themselves, and they may want to repeat various goals over time. For example, consumers often reengage goals such as losing weight, saving money, or improving their exercise or sports performance.

Long-term cigarette smoking impacts morbidity and mortality, no question about that, but there may be a good reason to stop smoking in the weeks before surgery even if you don't intend to quit overall. 

In a review article, researchers from the University of California San Francisco and Yale University examined neurosurgical literature to characterize the impact of active smoking on neurosurgical outcomes. They found strong evidence for the association between smoking and perioperative complications throughout the surgical literature. 

Scholars have linked higher IQ at early school age to weight gain and increased head size in the first month of a baby's life.

The results were determined - as apparently intelligence is - by analyzing data from more than 13,800 children who were born full-term.  

The findings in Pediatrics were that babies who put on 40% of their birth weight in the first four weeks had an IQ 1.5 points higher by the time they were six years of age, compared with babies who only put on 15% of their birth weight. Those with the biggest growth in head circumference also had the highest IQs.

Fibromyalgia is a blanket term for a general painful condition that affects approximately 10 million people in the United States.

Because it lacks consistent symptoms and treatments, some doctors believe an unknown number of instances are psychosomatic but a new paper in PAIN MEDICINE concludes that fibromyalgia may have a rational biological basis, located in the skin. 

Electric Batteries - by A. Volta

In this article I present my translation of Alessandro (Alexander) Volta's original French paper, which I published as -
Batteries électriques - By A. Volta