The 'war on cancer' has led to a reduction in the rate of cancer deaths whether measured against baseline rates in 1970 or in 1990, reports a new study by the American Cancer Society.
According to the study, the downturn in cancer deaths since 1990 is due mostly to reductions in tobacco use, increased screening allowing early detection of several cancers, and modest to large improvements in treatment for specific cancers. The study was published today in PLoS One.
Researchers used nationwide cancer mortality data for the years 1970 through 2006 from the SEER*Stat database, which defines major cancer sites consistently over time in order to facilitate reporting of long term mortality trends.
Spring training is just getting underway for Major League Baseball, and that means it's time for Bruce Bukiet, associate professor of Mathematics at the New Jersey Institute of Technology, to make his annual predictions about the outcome of the season.
Bukiet bases his predictions on a mathematical model he developed in 2000. His model computes the probability of a team winning a game against another team with given hitters, bench, starting pitcher, relievers and home field advantage. For this season, he incorporated a more realistic runner advancement model into the algorithm. Operations Research published Bukiet's mathematical model several years ago.
Researchers studying populations of numerous moth and butterfly species across Papua New Guinea have developed a new technique to study the spread and diet of insect pests--DNA barcoding, which involves the identification of species from a short DNA sequence.
DNA barcodes showed that migratory patterns and caterpillar diets are very dynamic. In one case, a tiny moth that is distributed from Taiwan to Australia, had recently crossed thousands of miles of Pacific Ocean.
The research is detailed in this week's edition of PNAS.
Sonic hedgehog, a gene that plays a crucial rule in the positioning and growth of limbs, fingers and toes, has been found in the ectoderm - the cell layer that gives rise to the skin - in the embryos of developing mice. The gene was previously thought to be exclusively present in the cell layer that builds bone and muscle, called the mesoderm.
The discovery, detailed in PNAS, suggests that Sonic hedgehog's role in the growth of appendages is far more complex than originally thought. Developmental biologists may have to rethink established theories about how limbs are patterned in vertebrates — an effort that could provide insight into human birth defects.
Writing in the latest issue of JAMA, Alec B. O'Connor, associate professor at the University of Rochester Medical Center, says the federal guidelines governing the approval of potential new drugs should be much more stringent. The FDA, according to the commentary, should require studies comparing the effectiveness and safety of a new drug to an established first-line drug when considering a drug for approval.
Currently the agency does not require such studies, known as "active comparator trials," though some large studies of new drugs do include them. In many cases, to gain approval, the main criterion besides safety is that a new drug must be shown to be more effective than placebo.
A team of astronomers writing in Astrophysical Journal Letters has shown that the two stars in the binary HM Cancri revolve around each other in a mere 5.4 minutes, making HM Cancri the binary star with by far the shortest known orbital period. It is also the smallest known binary; The system is no larger than 8 times the diameter of the Earth.
The team was able to prove the short binary period of the system by detecting the velocity variations in the spectral lines in the light of HM Cancri. These velocity variations are induced by the Doppler effect, caused by the orbital motion of the two stars revolving around each other. The Doppler effect causes the lines to periodically shift from blue to red and back.
Researchers at Yale School of Medicine have discovered that exposure during pregnancy to Bisphenol A (BPA), a common component of plastics, causes permanent abnormalities in the uterus of offspring, including alteration in their DNA. The findings were reported the Journal of the Federation of American Societies for Experimental Biology (FASEB J.).
The authors say the study is the first to show that BPA exposure permanently affects sensitivity to estrogen.
Scientists from the U.S. department of Agriculture have discovered how The Aedes aegypti mosquito detects the chemical structure of a compound called octenol as one way to find a mammalian host for a blood meal.
Scientists have long known that mosquitoes can detect octenol, but this most recent finding, published in PLoS One, explains in greater detail how Ae. aegypti--and possibly other mosquito species--detect the compound.
