Abnormally high levels of P-cadherin – an adhesion molecule that enables cells to bind together – occur in about a third of all breast cancers and are associated with poor prognosis. Portuguese researchers , writing in the journal Oncogene1, found that the reason why these cancers are more aggressive is because excessive P-cadherin changes the cancer cells’ internal organization, making them mobile and invasive (invasiveness is the capacity to cross biological barriers such as membranes). Both these characteristics allow the formation of metastases - which is the spread of cancer cells from the original site of the tumour to other parts of the body - increasing the disease aggressiveness and explaining the poor prognoses associated with P-cadherin.
Although the H1N1 vaccine is generally believed to be safe and effective, researchers from the University of Missouri have uncovered evidence that taking over-the-counter pain relievers, like aspirin and Tylenol, can reduce the effectiveness of the vaccine because they inhibit the normal function of enzymes that help regulate the immune system.
The role of these enzymes, called COX enzymes, is not yet understood completely, and
medications that inhibit them may have adverse side effects. Recent research has discovered that drugs that inhibit COX enzymes, such as COX-2, have an impact on the effectiveness of vaccines. This new research indicates that inhibiting COX-1, which is present in tissues
Cancer researchers at the University of Oklahoma have found a way to turn ineffective new cancer drugs into deceptive cancer-killers. By using a patented chemical compound called SHetA2, the researchers tricked cancer cells into responding to new treatments and committing suicide. Their new study appears in the journal Gynecologic Oncology.
"This discovery means that we can use our non-toxic cancer prevention pill to improve treatment for people who already have cancer," said Doris Mangiaracina Benbrook, Ph.D., principal investigator on the project. "All studies to date have not found any side effects of taking our drug, giving hope that we can prevent cancer in healthy people, and improve treatment for cancer patients, without increasing toxicity."
Political scientists from the University of Missouri say that the general public knows very little about foreign policy, and what they do know is based primarily on "rhetoric" from whatever president occupies the White House.
They also suggest that plainly stated, easy-to-understand foreign policy explanations from presidential administrations are likely to receive public support, while complicated, convoluted policy explanations are likely to face greater public skepticism. The findings are published in Political Research Quarterly.
