Traditionally, the genome has been viewed as a collection of DNA molecules that vary in composition between individuals and species, and variations that generate phenotypic differences have been assumed to occur in a more or less random manner. More recently, this view has been challenged by evidence that genomes are in fact reservoirs of adaptive phenotypic plasticity. This adaptive genome concept, where mutations that convey adaptive benefits are likely to occur at greater than random frequencies (Caporale 1999, 2000, 2003) represents a synthesis of ideas and evidence from several subfields and has its genesis in work by pioneers such as Dhobzhansky (1937), Dawkins (1976), McClintock (1984) and Trifinov (1989).

Tom Friedman, in his Friday's NY Times column (subscription required) comments on Walter Isaacson's new biography of Einstein and asks:

"If Einstein were alive today and learned science the boring way it is taught in so many U.S. schools, wouldn’t he have ended up at a Wall Street hedge fund rather than developing theories of relativity for a Nobel Prize?"

Joanna Scott just wrote a nice little review of what is going on at Nature Island (slurl) on Nature's Nascent blog since her return from the American Chemical Society meeting in Chicago. The Blue Obelisk Cemetery, where I give my students quiz races on Fridays was featured (only possible through help from Beth and Eloise - thanks again!).

Fans of Open Source Science (or just the open source concept in general) should take a look at Assignment Zero. Jay Rosen writes on the About page:

Inspired by the open-source movement, this is an attempt to bring journalists together with people in the public who can help cover a story. It's a collaboration among NewAssignment.Net, Wired, and those who choose to participate. The investigation takes place in the open, not behind newsroom walls. Participation is voluntary; contributors are welcome from across the Web. The people getting, telling and vetting the story are a mix of professional journalists and members of the public -- also known as citizen journalists.

A new study, led by Felix Aigner, M.D., has identified a protein known as Lipocalin-2 (Lcn-2) as potentially responsible for regulating the body's inflammatory response during heart transplants.

One of the major complications involved with many transplantations is the damage done to the transplanted heart during and immediately following surgery, known as ischemia and reperfusion (IR). In particular, inflammatory cells infiltrate the donated heart, which then releases enzymes and other proteins that attack the transplanted tissue, and can seriously impair the viability of replacement organs and jeopardize the health of the patient.

Researchers at Johns Hopkins have discovered that the same ingredient used in dandruff shampoos to fight the burning, itching and flaking on your head also can calm overexcited nerve cells inside your head, making it a potential treatment for seizures. Results of the study can be found online in Nature Chemical Biology.

In 1928, Alexander Fleming opened the door to treating bacterial infections when he stumbled upon the first known antibiotic in a Penicillium mold growing in a discarded experiment.

Nearly eight decades later, chemist Helen Blackwell and her research team at the University of Wisconsin-Madison have devised a more deliberate method to tackle a newer bacterial conundrum - resistance to commonly used antibiotics. Early tests of their tool, called a "small-molecule macroarray," have already identified four promising new compounds with preliminary antibacterial activity comparable to that of some of the most potent antibiotics currently available.

The mouth is a tough environment, which is why dentists do not give lifetime guarantees. Despite their best efforts, a filling may eventually crack under the stress of biting, chewing and teeth grinding, or secondary decay may develop where the filling binds to the tooth. Fully 70 percent of all dental procedures involve replacements to existing repairs, at a cost of $5 billion per year in the United States alone.

In a breakthrough that could make the production of cellulosic ethanol less expensive, Cornell researchers have discovered a class of plant enzymes that potentially could allow plant materials used to make ethanol to be broken down more efficiently than is possible using current technologies.

There is a growing recognition that corn ethanol is unlikely to provide a long-term solution, or one that is environmentally sustainable, and so scientists are turning to cellulose as an alternative.

This schematic diagram shows the newly discovered class of plant enzymes with a cellulose-binding module (shown in blue), sticking to a plant cell wall.

This study examined whether a traditional low-impact mind–body exercise, Tai Chi, affects health-related quality-of-life (HRQOL) and headache impact in an adult population suffering from tension-type headaches.

According to the National Headache Foundation, more than 45 million Americans suffer from chronic headaches, with losses of $50 billion a year to absenteeism and medical expenses and an excess of $4 billion spent on over-the-counter medications.

Tension-type headaches (TTH), which represent approximately 78% of all headaches, occur either in single episodes or chronically, and are often the result of temporary stress, anxiety, fatigue or anger.