In middle age we begin to lose myelin, the fatty sheath of "insulation" that coats our nerve axons and allows for fast signaling bursts in our brains. So if you want to be the best at anything requiring speedy brain reaction times, you'd better get it in by age 39.
Writing in Neurobiology of Aging, Dr. George Bartzokis, professor of psychiatry at the UCLA Semel Institute for Neuroscience and Human Behavior at UCLA, and colleagues compared how quickly a group of males ranging in age from 23 to 80 could perform a motor task and then correlated their performances to their brains' myelin integrity.
The researchers found a striking correlation between the speed of the task and the integrity of myelination over the range of ages. Put another way, after middle age, we start to lose the battle to repair the myelin in our brain, and our motor and cognitive functions begin a long, slow downhill slide.