In 2016, a Respiratory Syncytial Virus (RSV) vaccine candidate named the RSV F Vaccine failed in Phase III trials, which could have been a crippling blow for Novavax, but they may be on the road to recovery.

Companies have to have Phase III trials before they can get approval. Phase I proves safety and dosing while Phase II shows it is better than a placebo and Phase III is intended to show it either works better than existing treatments or has fewer side effects. That's all after numerical models and animal studies. Since FDA essentially doubled the costs to get drug approval in the early 2000s only the most promising drug advances to Phase III. perhaps 1 in 5,000 that look good on a computer. It simply isn't worth the cost otherwise.  

The protein complex AMPK is thought to suppress cancer, by slowing cellular metabolism, but it can also help some tumors grow.

But why? A new study says it has solved the mystery.

AMPK acts as a fuel gauge for the cell, overseeing energy input and output to keep the cell running smoothly. Similar to a car sensor flashing a low-gas signal or turning off a vehicle’s AC to save energy, AMPK slows down cell growth and changes the cell’s metabolism if the cell’s fuel (nutrients) is low.

The Great Pyramids have long been held up as the pinnacle of ancient engineering. Over 100 structures, some as high as were constructed of huge alabaster blocks, many quarried from Hatnub - the site of an new interesting discovery.

Given the challenges in building such huge structures, it is no surprised the Great Pyramid of Khufu is one of the Seven Wonders of the Ancient World. It and others were built thanks to quarries connected to the Nile by Bronze Age roads. The blocks were transported by sleds. But what about construction? Huge ramps? Were they poured? Some even speculated about aliens.

New molecules similar to carbohydrates have showed the capacity to inhibit the activity of a specific type of glycoside enzymes - and that means inhibiting infectious diseases.

Glycosides are essential enzymes to digest carbohydrates but they are also key players in infections caused by pathogens, in anti-bacterial defense and many other vital cellular processes. Because these small molecules that are able to bond with and inhibit the activity of enzymes in infectious diseases, it opens up the basis for new medicines. 

In his just published final book, "Brief Answers to the Big Questions," physicist Satephen Hawking wrote, "There is no God. No one directs the universe" but in a universe where only 6% of what must exist is even matter that can be detected, the science community is unwilling to be as definitive as he was.

It may be that God is in the gaps, and different people have different definitions for what that is. Yet it may be perpetuating the false narrative that religion is on one pole and science is on another.

Lyme disease is the most prevalent tick-borne disease and is caused by the bacterial spirochete Borrelia. Using the Centers for Disease Control and Prevention (CDC) recommended two-tier method, Garg et al., claim that 72 percent of individuals they examined classified "negative" by the CDC two-tier lyme disease test showed positive for the Borellia biomarker, and other microbes such as Babesia, Bartonella, and Ehrlichia.

That means some lyme disease patients do not follow the "one microbe, one disease" Germ Theory, according to an analysis of patients at different disease stages which found they respond to various microbes 65 percent of the time. And that ticks carry more than just lyme disease.