Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue. Before then, it may be necessary to decipher the epigenetic signals that give stem cells their unique ability to self-renew and transform them into different cell types.

The hype over epigenetic research is because it opens up the possibility of reprograming cells. By manipulating epigenetic marks, cells can be transformed into other cell types without changing their DNA. It is simply a question of adding or removing the chemical tags involved.

Stem cells rely heavily on epigenetic signals. As a stem cell develops, chemical tags on the DNA or its surrounding histone proteins switch genes on or off, controlling a cell’s fate.

As evidence mounts that the body's normally protective inflammation response can drive some precancerous tissues to become fully malignant, UCSF scientists report discovering an apparent trigger to this potentially deadly process.

Typically, the "innate" immune system's Pac-Man-like white blood cells, or leukocytes, engulf and destroy invading microbes when receptors on their surface receive a signal from serum in the blood -- often an antibody produced by a B cell in the separately evolved "acquired" immune system.

A special cocoa made to retain naturally occurring compounds called flavonols may have the potential to help maintain healthy brain function and chart the course for future research that could lead to new solutions for preventing cognitive decline and dementia, according to a panel of scientists who presented new data at the annual meeting of the American Association for the Advancement of Science (AAAS).

Several studies suggest that consumption of a special cocoa made to be rich in flavonols, a naturally occurring nutrient abundant in fresh cocoa, may improve blood vessel function.

At unprecedented levels of difficulty involving highly biodiverse and continent-sized landscapes, scientists have successfully tested their ability to identify and DNA "barcode" entire assemblages of species -- the prelude to a genetic portrait of all animal life on Earth.

Revealing their results in the UK journal Molecular Ecology Notes, they report having assembled a genetic portrait of birdlife in the U.S.

Give college students less instruction and more freedom to think for themselves in laboratory classes, and the result may be a four-fold increase in their test scores.

So says Steve Rissing, a professor of evolution, ecology and organismal biology at Ohio State University. Rissing played a major role in revamping the way the university teaches its introductory-level biology courses.

“For one, we got away from the cookbook method of teaching concepts of biology in a lab course,” he said. “Instead, many of those classes now include real experiments that leave room for additional inquiry.”

The effort paid off.

There is no such thing as a free lunch, some say, but they would be wrong. In fact, the entirety of the universe defies them. According to Stanford physics Professor Andrei Linde, one of the architects of the inflationary theory, our universe (and all the matter in it) was born out of a vacuum.

"Recent developments in cosmology have irreversibly changed our understanding of the structure and fate of our universe and of our own place in it," says Linde, who will discuss the inflationary view of the universe at the annual meeting of the American Association for the Advancement of Science on Feb.